Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4)
Official title: Alzheimer's Disease Neuroimaging Initiative (ADNI4)
Funded at Northern California Institute/res/edu · NIH-11592264 · Data updated 2026-11-12
A large study to validate biomarkers that help test Alzheimer's treatments and improve how we design trials for people at risk or with Alzheimer’s disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $396,505 |
| NIH project number | 3U19AG024904-19S4 |
| Project ID | NIH-11592264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at elevated risk for dementia or with Alzheimer’s disease who may participate in biomarker studies or data-sharing programs.
✕Less likely to help
Participation may not directly benefit all individuals, but contributes to broader understanding that could help future patients.
What this research studies
ADNI4 aims to advance the science of Alzheimer’s by validating blood, imaging, and other biomarkers that can guide clinical trials. The project will maintain and share extensive data and biospecimens, while following participants from prior ADNI studies and boosting enrollment of individuals at higher risk for dementia. Through dedicated recruitment, digital support, and a broad data-sharing effort, ADNI4 seeks to connect biomarker findings with cognitive decline and disease progression. This work builds on a long track record of contributing to major discoveries and FDA-directed treatment strategies.
Why it matters
Potential benefit: If successful, this work could make future Alzheimer's trials faster and more accurate, potentially accelerating the development of effective therapies.
How similar studies have gone: ADNI has a strong history of driving major advances in AD biomarker validation and trial design, with thousands of publications and impact on approved therapies.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Weiner, Michael W — Northern California Institute/res/edu
- Study coordinator: Weiner, Michael W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.