CiLostAzol for preventing recurrent stroke in Africa
Official title: CiLostAzol for pReventIon of recurrent sTroke in Africa (CLARITY-Africa)
Funded at Northern California Institute/res/edu · NIH-11582462 · Data updated 2026-11-12
This grant tests whether adding cilostazol to standard therapy can reduce recurrent stroke in stroke survivors in sub-Saharan Africa.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $408,097 |
| NIH project number | 3R01NS139346-03S1 |
| Project ID | NIH-11582462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in sub-Saharan Africa who have survived a stroke and are candidates for secondary prevention.
✕Less likely to help
Patients who cannot take cilostazol due to contraindications or who are in regions without access to necessary follow-up care may not benefit.
What this research studies
The project aims to show that cilostazol, taken twice daily, safely reduces the risk of another stroke in African patients who have already had one. It uses a hybrid study design to assess efficacy and safety in a low-resource setting while building local stroke research capacity. The study will involve active follow-up of participants and monitoring for adverse events, with a focus on affordability and applicability in sub-Saharan Africa. If successful, the findings could inform guidelines and improve long-term outcomes for stroke survivors in the region.
Why it matters
Potential benefit: If successful, patients could experience fewer recurrent strokes and better long-term survival in a resource-limited setting.
How similar studies have gone: Previous studies in Asian populations showed reduced major cardiovascular events with cilostazol added to antiplatelet therapy, but data in African populations are limited.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Ovbiagele, Bruce — Northern California Institute/res/edu
- Study coordinator: Ovbiagele, Bruce
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.