Eyes and autoimmune signals after Ebola: long-term eye issues and biology
Official title: Long-term ocular sequelae and biological determinants of post-acute Ebola virus disease
Funded at Northern California Institute/res/edu · NIH-11624741 · Data updated 2026-11-12
This grant looks at why some Ebola survivors develop long-lasting eye problems and what immune or biological clues might predict them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $164,410 |
| NIH project number | 3U01EY038042-02S1 |
| Project ID | NIH-11624741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ebola survivors with current or past ocular symptoms or risk factors for eye involvement.
✕Less likely to help
Patients without a history of Ebola infection or known ocular involvement may not benefit directly.
What this research studies
This study follows people who survived Ebola to track eye problems that can appear or persist years after infection. It will collect eye health data, blood samples, and immune markers to understand how autoimmunity and persistent viral clues relate to ocular sequelae. The goal is to identify patterns that could guide future treatments or prevention of vision loss in survivors. The research builds on a large prior cohort and uses ongoing follow-up to map how eye issues evolve over time.
Why it matters
Potential benefit: If successful, patients could receive earlier diagnosis and targeted therapies to protect vision after Ebola.
How similar studies have gone: Previous long-term studies have documented ocular sequelae in Ebola survivors; this project extends understanding of mechanisms and progression.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Kelly, John Daniel — Northern California Institute/res/edu
- Study coordinator: Kelly, John Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.