Alzheimer’s Disease Neuroimaging Initiative: improving biomarkers and trials
Official title: Alzheimer's Disease Neuroimaging Initiative (ADNI4)
Funded at Northern California Institute/res/edu · NIH-11592259 · Data updated 2026-11-12
A large NIH program is advancing how we measure Alzheimer’s disease and recruit people at risk so future treatments can be tested more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2004 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $136,595 |
| NIH project number | 3U19AG024904-19S1 |
| Project ID | NIH-11592259 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at elevated risk for dementia who may participate in long-term follow-up and biomarker studies.
✕Less likely to help
Participation may not directly benefit all individuals in the short term, but contributes to a larger knowledge base.
What this research studies
ADNI4 is a long-running effort to validate biomarkers for Alzheimer’s disease and to improve the design of upcoming clinical trials. The project maintains and shares extensive data, including clinical, cognitive, imaging, genetic, and biomarker information, plus biological samples, to help researchers understand how the disease progresses. ADNI4 aims to validate biomarkers, recruit more people at elevated risk for dementia, and expand access to digital and support resources for participants. The initiative builds on decades of work that influenced trial designs and helped bring therapies to FDA consideration. By following rollover participants and enhancing recruitment, it seeks to create a richer dataset for studying how biomarkers relate to cognitive decline and pathology.
Why it matters
Potential benefit: If successful, this project could streamline future trials and accelerate the development of effective Alzheimer’s therapies.
How similar studies have gone: ADNI has a long track record of high-impact publications and influence on trial design; this continuation aims to build on that success.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Weiner, Michael W — Northern California Institute/res/edu
- Study coordinator: Weiner, Michael W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.