Investigating cholesterol reduction and heart disease risk in Type 1 diabetes
Official title: Cholesterol reduction and cardiovascular risk in Type 1 diabetes
Funded at New York University School of Medicine · NIH-10899673 · Data updated 2026-11-12
This study is looking at how lowering LDL cholesterol can help heart health in people with Type 1 diabetes, and it’s inviting participants from different communities in New York City to try out cholesterol-lowering treatments for four weeks to see how their bodies respond.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $844,212 |
| NIH project number | 5R01HL164949-03 |
| Project ID | NIH-10899673 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 1 diabetes who are at risk for cardiovascular disease.
✕Less likely to help
Patients without Type 1 diabetes or those who do not have elevated LDL cholesterol levels may not benefit from this research.
What this research studies
This research focuses on understanding how reducing LDL cholesterol levels can impact cardiovascular health in patients with Type 1 diabetes. It aims to identify the biological pathways that are affected by cholesterol reduction and how these pathways can be targeted to improve vascular repair and reduce the risk of cardiovascular events. Patients will receive cholesterol-lowering treatments for four weeks, and their responses will be monitored through changes in blood cells and inflammatory markers. The study will recruit participants from diverse communities in New York City, ensuring a broad representation of patients.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing heart disease in individuals with Type 1 diabetes.
How similar studies have gone: Previous research has shown that cholesterol reduction can improve cardiovascular outcomes in non-diabetic populations, but this approach in Type 1 diabetes is still being explored.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Goldberg, Ira J — New York University School of Medicine
- Study coordinator: Goldberg, Ira J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.