Childhood Allergy and the Neonatal Environment: Early Life Airways and Asthma
Official title: Childhood Allergy and the NeOnatal Environment (CANOE): Early life epithelial development and asthma
Funded at University of Wisconsin-Madison · NIH-11430311 · Data updated 2026-11-12
A long-term study following newborns to age 5 to understand how early-life nose and airway biology, immune development, and the environment influence asthma risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 6, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,650,321 |
| NIH project number | 1R01AI202514-01 |
| Project ID | NIH-11430311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children from birth through age 5 who are part of the CANOE study and have nasal samples collected at planned time points.
✕Less likely to help
Children not enrolled in CANOE or who miss sample collection windows may not directly benefit.
What this research studies
This project follows children enrolled at birth to track how their airway microbiome, epigenetic marks, and gene activity change over the first five years of life. By collecting nasal cells at multiple time points, researchers will map how prenatal and early-life exposures shape the airway ecosystem and relate these patterns to asthma risk. The study uses genetic, epigenetic, and microbiome analyses to explore how environment and biology interact in early development. Results could point to new ways to prevent asthma beginning in infancy. Participation involves noninvasive nasal sampling during pediatric visits over several years.
Why it matters
Potential benefit: If successful, findings could lead to strategies to reduce asthma risk by targeting early-life airway biology and environmental influences.
How similar studies have gone: Previous pediatric airway studies have shown connections between early microbiome patterns and later asthma, supporting this approach but the full longitudinal causal links remain to be proven.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Singh, Anne Marie — University of Wisconsin-Madison
- Study coordinator: Singh, Anne Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.