Children's Allergy and Asthma Data Hub (CADRE)
Official title: Children's Allergy and Asthma Data Repository (CADRE) Supplement
Funded at University of Wisconsin-Madison · NIH-11345660 · Data updated 2026-11-12
This project builds a shared data hub that combines many childhood allergy and asthma birth-study records so researchers can find early-life factors that change a child's risk of asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 6, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $246,640 |
| NIH project number | 3U24AI179612-02S1 |
| Project ID | NIH-11345660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are families who took part in birth or infant cohort studies (including infants/children with or without allergies or asthma) and who permit their study data or biospecimens to be shared for pooled research.
✕Less likely to help
Patients who were never enrolled in relevant birth/infant cohorts or who lack early-life exposure or outcome data are unlikely to be included or to benefit directly from this repository.
What this research studies
This project creates a central, user-friendly repository that brings together data from many birth and infant cohort studies about allergies and asthma. The team will harmonize information like birth details, environmental exposures, genetics, and health outcomes so different studies can be compared and combined. They will start with the existing CREW dataset and invite additional cohorts nationwide to contribute data and use value-added services to make data easier to access and interpret. The goal is to speed up discoveries about prenatal and early-life factors that could be changed to prevent childhood asthma.
Why it matters
Potential benefit: If successful, the repository could help researchers identify preventable prenatal or early-life causes of childhood asthma and lead to better prevention strategies.
How similar studies have gone: This builds on prior successful cohort collaborations (like CREW) that have identified risk factors by pooling data, but CADRE aims to scale and standardize that approach more broadly.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Gern, James E. — University of Wisconsin-Madison
- Study coordinator: Gern, James E.
Related research
Other NIH-funded projects on the same topics.
-
Childhood Allergy and the Neonatal Environment: Early Life Airways and Asthma
A long-term study following newborns to age 5 to understand how early-life nose and airway biology, immune development, and the environment influence asthma risk.
-
Role of a special interferon-responsive T cell in allergies and asthma
A study explores a unique interferon-responsive T cell type that may influence allergies and asthma, aiming to understand why some people become allergic and how this T cell subset could affect airway inflammation.
-
Children's Allergy and Asthma Data Hub
A national data hub will pool and harmonize child allergy and asthma cohort data to help researchers discover ways to prevent asthma in kids.
-
Viral and Host Factors in Infant and Child Allergy and Asthma
This grant explores why some babies and young children develop asthma by studying how viruses, environment, and airway cells interact from birth.
-
How microRNAs control allergy and asthma
This work looks at tiny gene-regulating molecules called microRNAs to find molecular ways to reduce allergic inflammation in people with asthma.
-
A newly discovered interferon-responsive immune cell linked to allergies and asthma
Researchers are looking at whether a newly discovered interferon-responsive T cell helps protect people exposed to allergens from developing allergic reactions and asthma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.