Childhood allergy and early-life environment linked to asthma and eczema care
Official title: Childhood Allergy and the NeOnatal Environment (CANOE) ECHO Pediatric Follow-Up and New Enrollment
Funded at University of Wisconsin-Madison · NIH-11375189 · Data updated 2026-11-12
A study following children from infancy to understand how genes, the environment, and the skin and nasal bacteria affect asthma and atopic dermatitis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,592,761 |
| NIH project number | 5UH3OD035509-04 |
| Project ID | NIH-11375189 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are infants and young children at risk for allergic diseases, with exposure data available from prenatal and early-life periods.
✕Less likely to help
Children without exposure concerns or who do not develop allergic diseases may see limited direct benefit.
What this research studies
This project uses data from a large child health cohort to explore how exposures before and after birth, along with the microbiome and epigenetic changes in the nasal and skin barriers, relate to the development of wheezing, asthma, and eczema. Researchers will examine how neighborhood factors like air pollution and green space, plus individual microbiomes, may alter gene expression and DNA methylation in early life. The study will follow infants and their families over time to identify mechanistic links between environment, biology, and allergic diseases. Findings could point to new ways to prevent or reduce allergy-related conditions in children.
Why it matters
Potential benefit: If successful, the research could lead to better prevention and early interventions for asthma and eczema in children.
How similar studies have gone: Prior work has shown associations between early-life exposures and later allergy outcomes, with emerging links to epigenetic changes and epithelial biology.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Singh, Anne Marie — University of Wisconsin-Madison
- Study coordinator: Singh, Anne Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.