Cervical cancer outcomes in women with HIV in Zambia and aging biology
Official title: The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Funded at University of Tx Md Anderson Can Ctr · NIH-11418470 · Data updated 2026-11-12
A research project is studying how aging processes affect cervical cancer outcomes in women living with HIV in Zambia and what this means for their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $663,372 |
| NIH project number | 5R01CA284623-04 |
| Project ID | NIH-11418470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women living with HIV in Zambia who are diagnosed with cervical cancer and are candidates for chemoradiation therapy.
✕Less likely to help
Patients without HIV or without cervical cancer are not the target for this work.
What this research studies
The study looks at how biological aging may influence how cervical cancer behaves and responds to chemoradiation in women with HIV, especially in resource-limited settings. Researchers plan to examine epigenetic aging markers and how they relate to cancer progression and treatment toxicity. The goal is to identify age-related factors that could improve care for women with HIV who develop cervical cancer. The work will involve collaboration between U.S. and Zambia-based teams to analyze patient samples and clinical data.
Why it matters
Potential benefit: If successful, findings could lead to tailored treatment considerations for aging PLWH with cervical cancer, potentially improving outcomes and reducing toxicity.
How similar studies have gone: Preliminary data suggest aging and HIV influence cancer biology and treatment response, but direct studies in cervical cancer with HIV are limited.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lin, Lilie Leming — University of Tx Md Anderson Can Ctr
- Study coordinator: Lin, Lilie Leming
Related research
Other NIH-funded projects on the same topics.
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Biologic aging and immune outcomes in cervical cancer among women with HIV in Zambia
This project looks at how aging at the biological level affects cervical cancer outcomes for women living with HIV in Zambia.
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Aging and HIV-related cervical cancer outcomes in women in Zambia
This grant studies how aging and HIV affect cervical cancer outcomes in women, with a focus on how treatment toxicity and effectiveness may differ for those living with HIV.
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How biologic aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether accelerated biological aging tied to HIV changes immune function and treatment results for women with cervical cancer in Zambia.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether faster biological aging in women with HIV changes how they respond to standard chemoradiation for cervical cancer.
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How biological aging affects cervical cancer outcomes for women with HIV in Zambia
This project compares biological aging markers in women with HIV in Zambia to see if faster aging relates to worse side effects and cancer outcomes from standard chemoradiation.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This study is looking at how aging affects cervical cancer treatment in women with HIV in Zambia, aiming to find ways to improve care and support for those who may not have easy access to screening and treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.