Biologic aging and immune outcomes in cervical cancer among women with HIV in Zambia
Official title: The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Funded at University of Tx Md Anderson Can Ctr · NIH-11535233 · Data updated 2026-11-12
This project looks at how aging at the biological level affects cervical cancer outcomes for women living with HIV in Zambia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $68,809 |
| NIH project number | 3R01CA284623-04S2 |
| Project ID | NIH-11535233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women living with HIV in sub-Saharan Africa (specifically Zambia) who have cervical cancer and are undergoing chemoradiation therapy.
✕Less likely to help
Individuals without HIV or without cervical cancer, or those not undergoing CRT, may not directly benefit.
What this research studies
The study focuses on how aging-related changes in the immune system and DNA methylation may influence how cervical cancer behaves and responds to treatment in women with HIV in a low-resource setting. Researchers will compare epigenetic aging markers with cancer outcomes and treatment toxicity to understand if biologically older patients have worse outcomes. The work involves collecting samples and clinical data from participants to explore connections between aging, immunity, and cancer therapy response. Findings could help tailor screening, treatment, and supportive care for this vulnerable population.
Why it matters
Potential benefit: If successful, the study could lead to personalized care strategies that consider biological aging to improve cervical cancer outcomes for women living with HIV.
How similar studies have gone: Preliminary data suggest aging markers relate to cancer outcomes, but this specific combination (HIV, cervical cancer, epigenetic aging) is novel and exploratory.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lin, Lilie Leming — University of Tx Md Anderson Can Ctr
- Study coordinator: Lin, Lilie Leming
Related research
Other NIH-funded projects on the same topics.
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Aging and HIV-related cervical cancer outcomes in women in Zambia
This grant studies how aging and HIV affect cervical cancer outcomes in women, with a focus on how treatment toxicity and effectiveness may differ for those living with HIV.
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Cervical cancer outcomes in women with HIV in Zambia and aging biology
A research project is studying how aging processes affect cervical cancer outcomes in women living with HIV in Zambia and what this means for their treatment.
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How biologic aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether accelerated biological aging tied to HIV changes immune function and treatment results for women with cervical cancer in Zambia.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether faster biological aging in women with HIV changes how they respond to standard chemoradiation for cervical cancer.
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How biological aging affects cervical cancer outcomes for women with HIV in Zambia
This project compares biological aging markers in women with HIV in Zambia to see if faster aging relates to worse side effects and cancer outcomes from standard chemoradiation.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This study is looking at how aging affects cervical cancer treatment in women with HIV in Zambia, aiming to find ways to improve care and support for those who may not have easy access to screening and treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.