How biologic aging affects cervical cancer outcomes in women with HIV in Zambia
Official title: The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Funded at University of Tx Md Anderson Can Ctr · NIH-11412344 · Data updated 2026-11-12
This project looks at whether accelerated biological aging tied to HIV changes immune function and treatment results for women with cervical cancer in Zambia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $69,565 |
| NIH project number | 3R01CA284623-03S2 |
| Project ID | NIH-11412344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are women living with HIV in Zambia who have locally advanced cervical cancer and are planned to receive chemoradiation therapy.
✕Less likely to help
Women without HIV, those with very early-stage cervical cancer treated without chemoradiation, or people outside the study region are unlikely to receive direct benefit from this project.
What this research studies
If you join, researchers will collect medical information and blood or tumor samples from women with HIV who have cervical cancer and are receiving standard chemoradiation. They will measure biological age using DNA methylation "epigenetic clocks" and test immune markers in the samples. These measures will be compared with treatment side effects, tumor response, and survival to see if faster biological aging links to worse outcomes. The work takes place at clinics in Zambia and aims to find markers that could help guide care for women in similar settings.
Why it matters
Potential benefit: If successful, the findings could help identify women at higher risk of poor treatment response or toxicity so care and follow-up can be better personalized.
How similar studies have gone: Previous research has shown HIV is associated with accelerated epigenetic aging, but applying these aging measures to predict cervical cancer chemoradiation outcomes is largely new.
Where this research is happening
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University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lin, Lilie Leming — University of Tx Md Anderson Can Ctr
- Study coordinator: Lin, Lilie Leming
Related research
Other NIH-funded projects on the same topics.
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Biologic aging and immune outcomes in cervical cancer among women with HIV in Zambia
This project looks at how aging at the biological level affects cervical cancer outcomes for women living with HIV in Zambia.
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Aging and HIV-related cervical cancer outcomes in women in Zambia
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Cervical cancer outcomes in women with HIV in Zambia and aging biology
A research project is studying how aging processes affect cervical cancer outcomes in women living with HIV in Zambia and what this means for their treatment.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether faster biological aging in women with HIV changes how they respond to standard chemoradiation for cervical cancer.
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How biological aging affects cervical cancer outcomes for women with HIV in Zambia
This project compares biological aging markers in women with HIV in Zambia to see if faster aging relates to worse side effects and cancer outcomes from standard chemoradiation.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This study is looking at how aging affects cervical cancer treatment in women with HIV in Zambia, aiming to find ways to improve care and support for those who may not have easy access to screening and treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.