How aging affects cervical cancer outcomes in women with HIV in Zambia
The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
This project looks at whether faster biological aging in women with HIV changes how they respond to standard chemoradiation for cervical cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11412343 on NIH RePORTER |
What this research studies
You would be asked to provide blood and tumor samples and clinical information while receiving standard chemoradiation for cervical cancer. Researchers will measure biological age using DNA methylation markers and compare those measures with treatment side effects, tumor response, and survival. The team will compare women living with HIV to women without HIV to see whether accelerated aging helps explain outcome differences. Laboratory analysis will be done at the participating institutions and linked back to each patient’s clinical course.
Who could benefit from this research
Good fit: Ideal participants are women in Zambia diagnosed with locally advanced cervical cancer who are receiving standard chemoradiation, especially those living with HIV.
Not a fit: Women without cervical cancer or those not receiving chemoradiation are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the work could help personalize cancer care by identifying women with HIV who may need different monitoring or treatment because of accelerated biological aging.
How similar studies have performed: Prior research has shown people with HIV often show accelerated epigenetic aging, but applying these biological-aging markers to predict cervical cancer treatment outcomes is a new approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Lin, Lilie Leming — University of Tx Md Anderson Can Ctr
- Study coordinator: Lin, Lilie Leming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.