How aging affects cervical cancer outcomes in women with HIV in Zambia
Official title: The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Funded at University of Tx Md Anderson Can Ctr · NIH-11412343 · Data updated 2026-11-12
This project looks at whether faster biological aging in women with HIV changes how they respond to standard chemoradiation for cervical cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $27,888 |
| NIH project number | 3R01CA284623-03S1 |
| Project ID | NIH-11412343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are women in Zambia diagnosed with locally advanced cervical cancer who are receiving standard chemoradiation, especially those living with HIV.
✕Less likely to help
Women without cervical cancer or those not receiving chemoradiation are unlikely to receive direct benefit from this project.
What this research studies
You would be asked to provide blood and tumor samples and clinical information while receiving standard chemoradiation for cervical cancer. Researchers will measure biological age using DNA methylation markers and compare those measures with treatment side effects, tumor response, and survival. The team will compare women living with HIV to women without HIV to see whether accelerated aging helps explain outcome differences. Laboratory analysis will be done at the participating institutions and linked back to each patient’s clinical course.
Why it matters
Potential benefit: If successful, the work could help personalize cancer care by identifying women with HIV who may need different monitoring or treatment because of accelerated biological aging.
How similar studies have gone: Prior research has shown people with HIV often show accelerated epigenetic aging, but applying these biological-aging markers to predict cervical cancer treatment outcomes is a new approach.
Where this research is happening
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University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lin, Lilie Leming — University of Tx Md Anderson Can Ctr
- Study coordinator: Lin, Lilie Leming
Related research
Other NIH-funded projects on the same topics.
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Biologic aging and immune outcomes in cervical cancer among women with HIV in Zambia
This project looks at how aging at the biological level affects cervical cancer outcomes for women living with HIV in Zambia.
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Aging and HIV-related cervical cancer outcomes in women in Zambia
This grant studies how aging and HIV affect cervical cancer outcomes in women, with a focus on how treatment toxicity and effectiveness may differ for those living with HIV.
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Cervical cancer outcomes in women with HIV in Zambia and aging biology
A research project is studying how aging processes affect cervical cancer outcomes in women living with HIV in Zambia and what this means for their treatment.
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How biologic aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether accelerated biological aging tied to HIV changes immune function and treatment results for women with cervical cancer in Zambia.
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How biological aging affects cervical cancer outcomes for women with HIV in Zambia
This project compares biological aging markers in women with HIV in Zambia to see if faster aging relates to worse side effects and cancer outcomes from standard chemoradiation.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This study is looking at how aging affects cervical cancer treatment in women with HIV in Zambia, aiming to find ways to improve care and support for those who may not have easy access to screening and treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.