How aging affects cervical cancer outcomes in women with HIV in Zambia
Official title: The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia
Funded at University of Tx Md Anderson Can Ctr · NIH-10931755 · Data updated 2026-11-12
This study is looking at how aging affects cervical cancer treatment in women with HIV in Zambia, aiming to find ways to improve care and support for those who may not have easy access to screening and treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $760,825 |
| NIH project number | 5R01CA284623-02 |
| Project ID | NIH-10931755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women living with HIV in Zambia, particularly those who are at risk for cervical cancer.
✕Less likely to help
Patients who do not live in Zambia or who do not have HIV may not benefit from this research.
What this research studies
This research investigates the relationship between biological aging and cervical cancer outcomes among women living with HIV in Zambia. It focuses on how premature aging, often seen in individuals with HIV, may influence the effectiveness of standard treatments like chemoradiation therapy. By examining the epigenetic changes associated with aging, the study aims to understand disparities in cancer progression and treatment responses in this vulnerable population. The research seeks to improve access to cervical cancer screening and treatment for women in underserved communities.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for women living with HIV who are at risk for cervical cancer.
How similar studies have gone: Previous research has shown that understanding biological aging can impact treatment outcomes in cancer, suggesting this approach may yield valuable insights.
Where this research is happening
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University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Lin, Lilie Leming — University of Tx Md Anderson Can Ctr
- Study coordinator: Lin, Lilie Leming
Related research
Other NIH-funded projects on the same topics.
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Biologic aging and immune outcomes in cervical cancer among women with HIV in Zambia
This project looks at how aging at the biological level affects cervical cancer outcomes for women living with HIV in Zambia.
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Aging and HIV-related cervical cancer outcomes in women in Zambia
This grant studies how aging and HIV affect cervical cancer outcomes in women, with a focus on how treatment toxicity and effectiveness may differ for those living with HIV.
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Cervical cancer outcomes in women with HIV in Zambia and aging biology
A research project is studying how aging processes affect cervical cancer outcomes in women living with HIV in Zambia and what this means for their treatment.
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How biologic aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether accelerated biological aging tied to HIV changes immune function and treatment results for women with cervical cancer in Zambia.
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How aging affects cervical cancer outcomes in women with HIV in Zambia
This project looks at whether faster biological aging in women with HIV changes how they respond to standard chemoradiation for cervical cancer.
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How biological aging affects cervical cancer outcomes for women with HIV in Zambia
This project compares biological aging markers in women with HIV in Zambia to see if faster aging relates to worse side effects and cancer outcomes from standard chemoradiation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.