Investigating cell competition in lung diseases like pulmonary fibrosis and ARDS
Official title: Cell competition in pulmonary fibrosis and ARDS
Funded at Mayo Clinic Rochester · NIH-10912696 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs interact and how that affects conditions like pulmonary fibrosis and ARDS, with the goal of finding new ways to help people with these serious breathing problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 20, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $934,920 |
| NIH project number | 5R35HL161169-03 |
| Project ID | NIH-10912696 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with idiopathic pulmonary fibrosis or those who have experienced ARDS, particularly those with risk factors like older age or comorbidities.
✕Less likely to help
Patients with lung diseases unrelated to fibrosis or ARDS may not benefit from this research.
What this research studies
This research focuses on understanding how cell competition affects the development of pulmonary fibrosis and acute respiratory distress syndrome (ARDS). It examines the mechanisms behind chronic lung injury and the failure of lung cells to repair themselves properly, which can lead to severe respiratory issues. By studying the cellular interactions and responses in the lungs, the research aims to uncover potential therapeutic targets that could improve patient outcomes. The approach includes analyzing lung tissue samples and utilizing genetic and experimental models to gain insights into disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and survival rates for patients with pulmonary fibrosis and ARDS.
How similar studies have gone: Previous research on similar cellular mechanisms in lung diseases has shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: De Langhe, Stijn Piet Johan — Mayo Clinic Rochester
- Study coordinator: De Langhe, Stijn Piet Johan
Related research
Other NIH-funded projects on the same topics.
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Cell competition in lung fibrosis and ARDS
A Mayo Clinic team is studying how lung cells compete and repair after injury in people with severe lung diseases like IPF, ARDS, and after viral infections, to find ways to improve recovery.
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How lung cells compete in pulmonary fibrosis and ARDS
This project looks at how some lung cells outcompete others to help explain scarring in people with pulmonary fibrosis and sudden severe lung injury (ARDS).
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Molecular clues to progressive lung scarring
Researchers are studying how lung tissue becomes progressively scarred, focusing on cell signals and receptors that may drive fibrosis in people with lung disease.
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Alveolar Cell Dysfunction in Pulmonary Fibrosis: Using SFTPC Mutations to Find New Targets
This grant explores how rare SFTPC mutations in alveolar cells may drive IPF and seeks new molecular targets to improve treatment.
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Iron and scar-forming cells in the lungs (IPF)
Researchers are exploring how iron in the lungs may drive the scarring seen in idiopathic pulmonary fibrosis and whether this could lead to new therapies.
-
Repurposing Pyrvinium as an Inhaled Therapy for Idiopathic Pulmonary Fibrosis
A patient-friendly look at a project trying to use an existing drug, pyrvinium, as an inhaled treatment option for idiopathic pulmonary fibrosis (IPF).
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.