Investigating cell competition in lung diseases like pulmonary fibrosis and ARDS
Cell competition in pulmonary fibrosis and ARDS
This study is looking at how certain cells in the lungs interact and how that affects conditions like pulmonary fibrosis and ARDS, with the goal of finding new ways to help people with these serious breathing problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10912696 on NIH RePORTER |
What this research studies
This research focuses on understanding how cell competition affects the development of pulmonary fibrosis and acute respiratory distress syndrome (ARDS). It examines the mechanisms behind chronic lung injury and the failure of lung cells to repair themselves properly, which can lead to severe respiratory issues. By studying the cellular interactions and responses in the lungs, the research aims to uncover potential therapeutic targets that could improve patient outcomes. The approach includes analyzing lung tissue samples and utilizing genetic and experimental models to gain insights into disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with idiopathic pulmonary fibrosis or those who have experienced ARDS, particularly those with risk factors like older age or comorbidities.
Not a fit: Patients with lung diseases unrelated to fibrosis or ARDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and survival rates for patients with pulmonary fibrosis and ARDS.
How similar studies have performed: Previous research on similar cellular mechanisms in lung diseases has shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: De Langhe, Stijn Piet Johan — Mayo Clinic Rochester
- Study coordinator: De Langhe, Stijn Piet Johan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.