New treatment for pain caused by chemotherapy
Official title: Novel biologic to treat chemotherapy-induced neuropathic pain
Funded at Raft Pharmaceuticals, LLC · NIH-10706551 · Data updated 2026-11-12
This study is testing a new treatment called RFT1081 to help cancer patients who are dealing with painful nerve issues caused by chemotherapy, aiming to ease their pain without the usual side effects of pain meds.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Raft Pharmaceuticals, LLC NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 19, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,049,997 |
| NIH project number | 5R44CA271904-02 |
| Project ID | NIH-10706551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients experiencing chronic pain due to chemotherapy-induced peripheral neuropathy.
✕Less likely to help
Patients who are not undergoing chemotherapy or do not experience neuropathic pain may not benefit from this research.
What this research studies
This research investigates a novel biologic treatment aimed at alleviating chemotherapy-induced peripheral neuropathy (CIPN), which affects many cancer patients. The approach focuses on a candidate drug, RFT1081, that targets specific cells involved in pain signaling and inflammation. By modifying the lipid composition of these cells, the treatment seeks to reduce chronic pain without the side effects associated with traditional pain medications. Patients may receive this treatment through a direct spinal delivery method, which has shown promise in preclinical studies.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective long-term solution for managing pain in cancer patients undergoing chemotherapy.
How similar studies have gone: Previous research has shown promise in targeting neuroinflammation for pain relief, making this approach a potentially innovative advancement in pain management.
Where this research is happening
-
Raft Pharmaceuticals, LLC
San Diego, United States Active
Researchers
- Principal investigator: Kogan, Yakov — Raft Pharmaceuticals, LLC
- Study coordinator: Kogan, Yakov
Related research
Other NIH-funded projects on the same topics.
-
Safer non-opioid medicines for nerve pain from chemotherapy
Testing new versions of the pain drug flupirtine to help people with chemotherapy-related nerve pain while lowering the risk of liver damage.
-
CBD-based formulation to relieve chemotherapy-induced nerve pain
A cannabidiol-based treatment is being studied to help people with nerve pain caused by certain chemotherapy drugs.
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Developing safer pain relief options for cancer patients experiencing neuropathic pain from chemotherapy
This study is looking for safer pain relief options for cancer patients dealing with nerve pain from chemotherapy by creating new versions of an old medication, flupirtine, that was taken off the market due to safety issues.
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Identifying biomarkers for neuropathic pain caused by chemotherapy
This study is looking at how certain biological markers in your body can help doctors figure out if you might experience nerve pain from chemotherapy before you start treatment, so they can tailor your care to reduce pain and improve your overall experience.
-
Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer
A patient-friendly approach tests a light-activated method to make ovarian cancer metastases more sensitive to chemotherapy.
-
Peripheral nerve stimulation for chronic neuropathic pain in a new mechanistic trial
A study at Stanford tests whether a painless-sounding electrical nerve treatment helps people with long-standing neuropathic pain when added to standard care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.