Identifying biomarkers for neuropathic pain caused by chemotherapy
Official title: Multi-Omic Biomarkers for Neuropathic Pain Secondary to Chemotherapy
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10914172 · Data updated 2026-11-12
This study is looking at how certain biological markers in your body can help doctors figure out if you might experience nerve pain from chemotherapy before you start treatment, so they can tailor your care to reduce pain and improve your overall experience.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $932,268 |
| NIH project number | 5R33NS113258-03 |
| Project ID | NIH-10914172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer patients who are about to start chemotherapy with taxanes.
✕Less likely to help
Patients who are not undergoing chemotherapy or those with other types of cancer unrelated to taxane treatment may not benefit from this research.
What this research studies
This research investigates how certain biological markers can predict which breast cancer patients will develop neuropathic pain as a side effect of chemotherapy with taxanes. By analyzing various biological samples, including blood, the study aims to identify specific signatures that indicate a patient's risk for this painful condition before treatment begins. This could help doctors make personalized decisions about chemotherapy dosing to minimize pain and improve overall treatment outcomes. The research employs advanced techniques to assess genetic, epigenetic, and metabolic factors associated with pain responses.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment plans that reduce the risk of debilitating neuropathic pain in breast cancer patients undergoing chemotherapy.
How similar studies have gone: Other research has shown promise in identifying biomarkers for chemotherapy side effects, suggesting that this approach could be effective.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Rotroff, Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Rotroff, Daniel
Related research
Other NIH-funded projects on the same topics.
-
Safer non-opioid medicines for nerve pain from chemotherapy
Testing new versions of the pain drug flupirtine to help people with chemotherapy-related nerve pain while lowering the risk of liver damage.
-
CBD-based formulation to relieve chemotherapy-induced nerve pain
A cannabidiol-based treatment is being studied to help people with nerve pain caused by certain chemotherapy drugs.
-
Developing safer pain relief options for cancer patients experiencing neuropathic pain from chemotherapy
This study is looking for safer pain relief options for cancer patients dealing with nerve pain from chemotherapy by creating new versions of an old medication, flupirtine, that was taken off the market due to safety issues.
-
New treatment for pain caused by chemotherapy
This study is testing a new treatment called RFT1081 to help cancer patients who are dealing with painful nerve issues caused by chemotherapy, aiming to ease their pain without the usual side effects of pain meds.
-
Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer
A patient-friendly approach tests a light-activated method to make ovarian cancer metastases more sensitive to chemotherapy.
-
Peripheral nerve stimulation for chronic neuropathic pain in a new mechanistic trial
A study at Stanford tests whether a painless-sounding electrical nerve treatment helps people with long-standing neuropathic pain when added to standard care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.