Identifying biomarkers for neuropathic pain caused by chemotherapy
Multi-Omic Biomarkers for Neuropathic Pain Secondary to Chemotherapy
This study is looking at how certain biological markers in your body can help doctors figure out if you might experience nerve pain from chemotherapy before you start treatment, so they can tailor your care to reduce pain and improve your overall experience.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10914172 on NIH RePORTER |
What this research studies
This research investigates how certain biological markers can predict which breast cancer patients will develop neuropathic pain as a side effect of chemotherapy with taxanes. By analyzing various biological samples, including blood, the study aims to identify specific signatures that indicate a patient's risk for this painful condition before treatment begins. This could help doctors make personalized decisions about chemotherapy dosing to minimize pain and improve overall treatment outcomes. The research employs advanced techniques to assess genetic, epigenetic, and metabolic factors associated with pain responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who are about to start chemotherapy with taxanes.
Not a fit: Patients who are not undergoing chemotherapy or those with other types of cancer unrelated to taxane treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment plans that reduce the risk of debilitating neuropathic pain in breast cancer patients undergoing chemotherapy.
How similar studies have performed: Other research has shown promise in identifying biomarkers for chemotherapy side effects, suggesting that this approach could be effective.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Rotroff, Daniel — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Rotroff, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.