Catheter Ablation vs Antiarrhythmic and Heart Failure Drug Therapy for AF with HFpEF
Official title: 2/2 Catheter Ablation Versus Antiarrhythmic and Heart Failure Drug Therapy in Preserved Ejection Fraction Heart Failure (CABANA-HF)
Funded at Duke University · NIH-11281051 · Data updated 2026-11-12
This project tests whether ablation or drug therapy improves outcomes for people with atrial fibrillation and heart failure with preserved ejection fraction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 10, 2026 |
| Project end | June 30, 2033 |
| Funding year | 2026 |
| Award (this year) | $1,571,639 |
| NIH project number | 1U24HL183692-01 |
| Project ID | NIH-11281051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with coexisting atrial fibrillation and HFpEF who are candidates for ablation or drug therapy.
✕Less likely to help
Patients not eligible for ablation or those with contraindications to the studied medications may not benefit.
What this research studies
If you have both atrial fibrillation and HFpEF, your heart may not pump efficiently and symptoms can be worse. The study compares catheter ablation against antiarrhythmic drugs and heart failure medications to see which approach better improves heart function and symptoms. Researchers will enroll patients, follow them over time, and monitor safety, hospitalizations, and quality of life. The goal is to identify the best treatment path for people with this common and challenging combination of conditions.
Why it matters
Potential benefit: If successful, this work could guide clinicians on the most effective treatment to improve function and reduce hospital visits for patients with AF and HFpEF.
How similar studies have gone: Previous studies suggest complex interactions between AF and HFpEF; this trial aims to provide clear comparative evidence.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Al-Khalidi, Hussein — Duke University
- Study coordinator: Al-Khalidi, Hussein
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.