Catheter ablation plus standard heart failure care in HFpEF with atrial fibrillation
Official title: (1/2) Catheter Ablation Versus Antiarrhythmic and Heart Failure Drug Therapy in Preserved Ejection Fraction Heart Failure (CABANA-HF)
Funded at Ihc Health Services, INC. · NIH-11281754 · Data updated 2026-11-12
A large multi-center study will test whether adding catheter ablation for atrial fibrillation to guideline-based heart failure treatment improves outcomes for people with HFpEF and AF.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ihc Health Services, INC. NIH-funded |
| Lab location | 1 site (Salt Lake City, UNITED STATES) |
| Project start | July 10, 2026 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,293,639 |
| NIH project number | 1UG3HL182948-01 |
| Project ID | NIH-11281754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with heart failure with preserved ejection fraction and atrial fibrillation who are eligible for ablation and GDMT.
✕Less likely to help
Patients who have contraindications to ablation or cannot receive GDMT may not benefit.
What this research studies
This trial will compare a one-time catheter ablation procedure plus standard heart failure therapy against standard therapy alone in patients with heart failure with preserved ejection fraction and atrial fibrillation. It aims to enroll about 1,552 participants across multiple centers over five years, with three years of recruitment and two years of follow-up. A blinded Clinical Events Committee will review major outcomes to ensure objective results. By examining outcomes like heart failure hospitalizations and mortality, the study seeks to understand if ablation offers added benefit across different patient subtypes and levels of atrial myopathy. If successful, findings could refine treatment guidelines for HFpEF patients with AF.
Why it matters
Potential benefit: If successful, the study could clarify whether adding AF ablation improves survival and reduces heart failure worsening for HFpEF patients with AF.
How similar studies have gone: Previous data suggest potential benefits of rhythm-control strategies, but definitive results in HFpEF/AF populations are still needed, making this trial important and somewhat exploratory.
Where this research is happening
-
Ihc Health Services, INC.
Salt Lake City, United States Active
Researchers
- Principal investigator: Packer, Douglas L — Ihc Health Services, INC.
- Study coordinator: Packer, Douglas L
Related research
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Catheter Ablation vs Antiarrhythmic and Heart Failure Drug Therapy for AF with HFpEF
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.