Cardiovascular health with different dialysis strategies in twice- vs thrice-weekly treatment
Official title: The Impact on Cardiovascular Health with Different Hemodialysis Strategies: The TwoPlus CV Study
Funded at Wake Forest University Health Sciences · NIH-11343747 · Data updated 2026-11-12
This study compares two ways of starting dialysis to see how heart and vessel health and outcomes differ for people beginning dialysis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $883,723 |
| NIH project number | 1R01HL185419-01 |
| Project ID | NIH-11343747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults initiating maintenance hemodialysis who have residual kidney function and are candidates for incremental (twice-weekly) dialysis with clinical support.
✕Less likely to help
Patients without residual kidney function or those not suitable for incremental initiation may not benefit from the two-plus strategy.
What this research studies
This project enrolls adults starting maintenance hemodialysis who have some remaining kidney function and compares a patient-tailored, incremental approach starting with twice-weekly dialysis to the standard thrice-weekly approach. It uses clinical data, patient monitoring, and pharmacologic support to tailor treatment and track heart-related outcomes over time. The study sits within a larger multicenter trial and aims to determine whether the personalized approach leads to fewer emergency visits, hospitalizations, or deaths without sacrificing effectiveness. If successful, this work could influence how dialysis is started to protect cardiovascular health. The ancillary study will prospectively collect cardiovascular and clinical data to understand the impact on heart structure and vascular health.
Why it matters
Potential benefit: If successful, patients may start dialysis with a safer, more personalized plan that protects heart health and reduces urgent healthcare needs.
How similar studies have gone: Prior work suggests tailoring dialysis intensity can influence cardiovascular outcomes, but the exact cardiovascular effects of the TwoPlus approach require confirmation in this trial.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Murea, Mariana — Wake Forest University Health Sciences
- Study coordinator: Murea, Mariana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.