The effects of exercise on cognitive function and aging in older adults

Epigenetic Aging Cognitive Function and Exercise in Older Adults

NIH-funded research University of Pittsburgh at Pittsburgh · NIH-10980240

This study is looking at how exercise can help older adults, especially those 65 and up, stay sharp mentally and age better, while also exploring how things like social factors and personal fitness responses play a role in brain health.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Pittsburgh at Pittsburgh NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-10980240 on NIH RePORTER

What this research studies

This research investigates how exercise influences cognitive function and biological aging in older adults, particularly those aged 65 and older. It aims to understand the relationship between epigenetic aging and cognitive decline, including conditions like Alzheimer's disease. By examining factors such as social determinants of health and individual responses to exercise, the study seeks to identify biological markers that could predict cognitive health outcomes. Participants will engage in exercise interventions while their cognitive function and biological markers are monitored over time.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 65 and above who are non-cognitively impaired and interested in improving their cognitive health through exercise.

Not a fit: Patients with advanced cognitive impairment or those unable to participate in exercise may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to personalized exercise recommendations that help maintain or improve cognitive function in older adults.

How similar studies have performed: Previous research has shown promising results regarding the benefits of exercise on cognitive function in older adults, indicating that this approach is both relevant and potentially impactful.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.