Biomarker-based guidance to predict meningioma outcomes and radiotherapy response
Official title: Validation, translation, and clinical implementation of a gene expression biomarker to predict meningioma outcomes and radiotherapy responses
Funded at University of California, San Francisco · NIH-11394565 · Data updated 2026-11-12
A gene-based test is being developed to help predict how meningioma tumors will behave and how patients may respond to radiotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $298,064 |
| NIH project number | 5UH3CA298962-02 |
| Project ID | NIH-11394565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with meningioma who are candidates for surgery or radiotherapy and whose tumor biology can be assessed by the biomarker.
✕Less likely to help
Patients with tumors not driven by the biomarker or those not undergoing detectable biomarker testing may not benefit.
What this research studies
This project aims to translate a gene expression biomarker into a clinical tool that can forecast meningioma outcomes and RT response, helping clinicians tailor treatment plans. The team will validate the biomarker, translate it to clinical use, and implement it in practice at UCSF. Patients with meningioma would be considered for biomarker-driven decisions that could influence surgical and radiotherapy strategies, potentially reducing unnecessary treatments and long-term side effects. The work involves analyzing patient tumor samples and clinical data to connect gene expression with real-world treatment outcomes.
Why it matters
Potential benefit: If successful, patients could receive more personalized treatment plans that maximize tumor control while minimizing harmful side effects from therapy.
How similar studies have gone: Previous research supports that gene-expression patterns can relate to treatment response, but translation into routine clinical use remains an ongoing effort.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Raleigh, David R — University of California, San Francisco
- Study coordinator: Raleigh, David R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.