Autoantibodies and membrane repair in myositis
Official title: Autoantibodies to membrane repair proteins in myositis
Funded at Ohio State University · NIH-11381103 · Data updated 2026-11-12
A blood and tissue study seeks to understand how immune reactions against muscle repair proteins contribute to inflammatory myositis, with the goal of guiding better treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 24, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $425,855 |
| NIH project number | 5R01AR084518-03 |
| Project ID | NIH-11381103 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with idiopathic inflammatory myopathies or clinicians seeking new therapeutic avenues; this project is primarily preclinical, with a focus on mechanisms rather than recruiting patients.
✕Less likely to help
Individuals without inflammatory myopathies or without involvement of muscle membrane repair pathways may not directly benefit from the study.
What this research studies
This project uses mouse models that mimic human inflammatory myopathies to explore how autoantibodies targeting membrane repair proteins relate to muscle inflammation. Researchers will study how internal muscle proteins presented by the immune system might trigger disease and how defects in membrane repair influence illness progression. Results could point to new strategies that reduce harmful immune responses while preserving muscle repair. The work builds on existing models that combine membrane repair defects with regulatory T cell problems to reproduce myositis features.
Why it matters
Potential benefit: If successful, the findings could inform future therapies that target specific immune pathways or membrane repair processes to lessen muscle damage in myositis.
How similar studies have gone: Similar preclinical models have shown that membrane repair defects and immune dysregulation can drive muscle inflammation, supporting a translational potential.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Jarjour, Wael N — Ohio State University
- Study coordinator: Jarjour, Wael N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.