Autoantibodies against muscle membrane repair proteins in myositis
Autoantibodies to membrane repair proteins in myositis
This work looks at whether people with myositis have antibodies that attack proteins that fix damaged muscle cell membranes and how that may cause muscle inflammation and weakness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11196770 on NIH RePORTER |
What this research studies
Researchers will use mouse models that lack key membrane repair proteins and models with regulatory T cell defects to recreate myositis-like muscle inflammation and study how immune cells and antibodies cause injury. They will perform adoptive transfer experiments and lab studies of muscle cells and tissues to trace how damaged muscle proteins become visible to the immune system. The team aims to identify specific autoantibodies to membrane repair proteins and to show how those antibodies interfere with the membrane repair process and promote ongoing muscle inflammation. Findings will be compared to human disease samples when available to link the mouse results to patients with idiopathic inflammatory myopathies.
Who could benefit from this research
Good fit: Adults with idiopathic inflammatory myopathies (myositis) such as polymyositis, dermatomyositis, or other immune-mediated myopathies, especially those with recent or active muscle weakness and who can donate blood or tissue samples, would be ideal candidates to inform this work.
Not a fit: People without immune-mediated myositis or those with long-standing, irreversible muscle damage are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this could lead to tests that detect harmful autoantibodies and to new treatments that protect muscle membrane repair and reduce muscle weakness in myositis patients.
How similar studies have performed: Previous mouse studies have shown that defective membrane repair can lead to mild myositis and that immune cell transfer can cause muscle inflammation, but identifying autoantibodies to repair proteins in patients would be a novel advance.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Jarjour, Wael N — Ohio State University
- Study coordinator: Jarjour, Wael N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.