Understanding how Chikungunya virus causes long-lasting joint and muscle pain
Pathogenesis of Alphavirus induced Chronic Arthritis and Myositis
This study is looking into how the Chikungunya virus can cause long-lasting joint and muscle pain in some people, and it aims to find out how the virus sticks around in the body so we can develop better treatments for those who are suffering.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11112490 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of Chikungunya virus infection, particularly focusing on how it leads to chronic arthritis and muscle pain in some patients. By studying infected cells in a mouse model, researchers aim to identify the mechanisms that allow the virus to persist in the body and cause ongoing inflammation. The study will analyze specific immune cells and their role in maintaining this chronic condition, which could lead to new treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced Chikungunya virus infection and are suffering from chronic joint and muscle pain.
Not a fit: Patients who have not been infected with Chikungunya virus or do not experience chronic symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from chronic arthritis and muscle pain caused by Chikungunya virus.
How similar studies have performed: Previous research on similar viral infections has shown promise in understanding chronic inflammatory responses, suggesting that this approach may yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Lenschow, Deborah J — Washington University
- Study coordinator: Lenschow, Deborah J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.