APOL1 Gene Variants in Kidney Donors and Long-Term Transplant Outcomes
Official title: 1-13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center
Funded at University of Miami School of Medicine · NIH-11373045 · Data updated 2026-11-12
This grant studies how APOL1 gene variants in kidney donors affect long-term results for people who receive kidney transplants.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 25, 2017 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $129,373 |
| NIH project number | 5U01DK116101-09 |
| Project ID | NIH-11373045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include kidney transplant recipients and living donors participating in APOLLO or enrolled via the participating centers.
✕Less likely to help
Patients not involved in kidney transplantation or without APOLLO enrollment may not directly benefit.
What this research studies
The project focuses on APOL1 gene mutations and their link to graft survival in kidney transplant recipients and living donors. It uses observational data from a consortium of transplant centers to follow participants over time. The goal is to understand whether donor APOL1 status influences transplant outcomes and to improve donor-recipient matching and post-transplant care. Privacy and consent are maintained while aggregating data across multiple sites to identify meaningful risk factors.
Why it matters
Potential benefit: If successful, the work could lead to better donor selection and personalized post-transplant management to improve graft longevity.
How similar studies have gone: APOLLO has previously enrolled hundreds of recipients and donors, showing the feasibility of large observational studies in this area.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Fornoni, Alessia — University of Miami School of Medicine
- Study coordinator: Fornoni, Alessia
Related research
Other NIH-funded projects on the same topics.
-
Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
-
Complement-Bound Exosomes and Kidney Transplant Immunity
This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.
-
Blood vessel signals predicting heart problems after kidney transplant
This project studies blood markers and tissue patterns after kidney transplants to identify which patients are at highest risk of cardiovascular problems.
-
Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Characterization of a LILRB3 SNP cluster and its link to kidney transplant outcomes
A study in kidney transplant recipients looks at genetic factors that may be tied to higher risk of graft failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.