Aging with AML: Understanding how venetoclax plus low-intensity therapy affects older adults
Official title: Aging trajectories and outcomes of older adults with acute myeloid leukemia
Funded at University of Nebraska Medical Center · NIH-11369153 · Data updated 2026-11-12
This project looks at how a newer AML treatment works for adults aged 60 and older, focusing on how it affects thinking, daily activities, and independence.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | July 12, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $515,428 |
| NIH project number | 5R37CA276928-04 |
| Project ID | NIH-11369153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 60 years and older with AML who are considering or receiving venetoclax-based low-intensity therapy.
✕Less likely to help
Patients who are not candidates for venetoclax-based therapy or who have conditions that limit study participation may not benefit.
What this research studies
The study follows older adults with AML treated with venetoclax and low-intensity chemotherapy to understand changes in cognitive function, daily living, and quality of life. It builds on preliminary findings showing some patients maintain or improve function after starting therapy, while frailty and multiple health issues can influence outcomes. Researchers will use EEG/ERP and other methods to explore brain activity patterns related to attention and executive function before and after treatment. The goal is to identify factors that predict who benefits most and who may need additional support.
Why it matters
Potential benefit: If successful, findings could help clinicians tailor treatments to preserve function and independence for older AML patients.
How similar studies have gone: Preliminary results suggest some patients maintain or improve cognitive and physical function during newer AML therapies, but more data are needed.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Bhatt, Vijaya Raj — University of Nebraska Medical Center
- Study coordinator: Bhatt, Vijaya Raj
Related research
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Understanding how older adults with acute myeloid leukemia fare with new treatments
This project looks at how new treatments for acute myeloid leukemia affect the daily lives and thinking abilities of older adults.
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Understanding how older adults with acute myeloid leukemia age and respond to treatment
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Researchers are testing a new approach to treat acute myeloid leukemia by disrupting how AML cells manage their proteins, with the goal of helping patients live longer and healthier lives.
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Understanding how epigenetic helper proteins drive AML and how to target them
A scientist team is studying how accessory proteins in gene-regulating complexes affect acute myeloid leukemia and whether they can be targeted for safer, more precise therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.