Understanding how older adults with acute myeloid leukemia age and respond to treatment
Aging trajectories and outcomes of older adults with acute myeloid leukemia
This study is looking at how new treatments for acute myeloid leukemia (AML) affect the thinking skills and daily lives of older adults, aiming to help them maintain their independence and improve their quality of life.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10886813 on NIH RePORTER |
What this research studies
This research investigates the aging trajectories and outcomes of older adults diagnosed with acute myeloid leukemia (AML), focusing on how new treatments, particularly a combination of venetoclax and low-intensity chemotherapy, affect cognitive function and daily living activities. The study aims to identify the risks of cognitive decline and loss of independence associated with these treatments, while also exploring factors that may influence these outcomes. By utilizing advanced techniques like electroencephalography (EEG), the research seeks to provide insights into the brain's activity in response to treatment. Ultimately, the goal is to improve the quality of life for older adults facing this challenging diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 60 and above who have been diagnosed with acute myeloid leukemia.
Not a fit: Patients who are younger than 60 years or those with other significant health conditions that preclude participation in treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance cognitive function and independence for older adults with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results with similar treatment approaches in improving cognitive function and quality of life in older adults with hematological cancers.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Bhatt, Vijaya Raj — University of Nebraska Medical Center
- Study coordinator: Bhatt, Vijaya Raj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.