Aging, DNA Methylation, and Cardio Risk in Breast Cancer Survivors
Official title: Aging, DNA methylation, and incident cardiovascular disease in breast cancer survivors
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-11378753 · Data updated 2026-11-12
A study to help breast cancer survivors understand how aging and DNA changes might raise the chance of heart disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $655,534 |
| NIH project number | 5R37CA299472-02 |
| Project ID | NIH-11378753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Breast cancer survivors who have completed initial cancer treatment and are at risk for cardiovascular disease may be eligible.
✕Less likely to help
Patients without breast cancer history or those not at risk for cardiovascular disease may derive less direct benefit.
What this research studies
This project looks at how aging-related DNA methylation and biological aging markers relate to cardiovascular disease risk in breast cancer survivors. Researchers will examine DNA from blood samples and identify methylation patterns that could predict who is at higher heart-disease risk after cancer treatment. The study aims to fine-tune risk models for breast cancer patients so clinicians can tailor heart-monitoring and treatment decisions. If successful, these biomarkers could lead to earlier intervention and personalized care for survivors. The effort involves follow-up with patients and analysis of their clinical and biomarker data over time.
Why it matters
Potential benefit: Better, personalized heart-health risk prediction for breast cancer survivors could guide prevention and treatment decisions.
How similar studies have gone: Prior work suggests DNA methylation and aging markers relate to cardiovascular risk, but applying this to breast cancer survivors is an emerging area.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Kresovich, Jacob K — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Kresovich, Jacob K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.