Adapting penicillin allergy checks in outpatient clinics
Official title: Adapting and Implementing Risk-Stratified Penicillin Allergy Evaluation in Key Outpatient Settings
Funded at Vanderbilt University Medical Center · NIH-11425328 · Data updated 2026-11-12
Aims to help people with penicillin allergy labels get safer, more effective antibiotics by using risk-based checks in outpatient settings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 30, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $479,248 |
| NIH project number | 5R01HS030234-03 |
| Project ID | NIH-11425328 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with a penicillin allergy label facing outpatient surgical, transplant, or obstetric care.
✕Less likely to help
Patients without a penicillin allergy label or those with high-risk allergies may not benefit directly.
What this research studies
This project builds on prior work to extend risk-stratified penicillin allergy evaluation to outpatient surgical, transplant, and obstetric care. It will measure how well outpatient allergy assessments work, identify barriers and facilitators, and develop a patient-friendly self-assessment tool. The team plans to pilot these assessments in pre-surgical clinics to support safer antibiotic prescribing and antimicrobial stewardship. The approach uses the ADAPT-ITT framework to adapt for multiple outpatient settings and activities. If successful, it could create a scalable model for reliably removing low-risk penicillin allergy labels at the point of care.
Why it matters
Potential benefit: If successful, patients with true penicillin allergies could receive first-line antibiotics more often, improving treatment effectiveness and reducing complications.
How similar studies have gone: Previous work showed high negative predictive value for low-risk delabeling and successful non-allergist delabeling in hundreds of patients.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Stone, Cosby a — Vanderbilt University Medical Center
- Study coordinator: Stone, Cosby a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.