Understanding and treating a specific type of esophageal cancer with high NRF2 levels

Who could benefit from this research

What this research studies

This research focuses on esophageal squamous cell carcinoma (ESCC) that has high levels of NRF2, a protein that may drive cancer growth. The team will use genetic and pharmacological methods to explore how NRF2 is activated and how it interacts with other cellular pathways. By identifying the mechanisms behind this hyperactivation, they aim to develop targeted therapies that could inhibit NRF2 and improve treatment outcomes for patients with this aggressive cancer. The research includes testing small molecule inhibitors that could potentially be used in clinical settings if proven effective.

Why it matters

Where this research is happening

• Coriell Institute for Medical Research
  Camden, United States Active

Researchers

• Principal investigator: Chen, Xiaoxin Luke — Coriell Institute for Medical Research
• Study coordinator: Chen, Xiaoxin Luke

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.