Condition

Treatment-resistant Schizophrenia clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 11Countries

Newest Treatment-resistant Schizophrenia clinical trials

All recruiting trials (9)

• Sequential Treatment Approaches for Treatment-Resistant Schizophrenia in Chinese Patients

  This trial tests whether clozapine-based drug therapy or neuromodulation with MECT or MST is better for adults in China who have treatment-resistant schizophrenia.

  Recruiting Phase 3 Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT07918222

• Nitraria Retusa Infusion for Clozapine-Related Metabolic Side Effects in Treatment-Resistant Schizophrenia

  A daily Nitraria retusa leaf infusion is tested for 90 days to see if it helps with metabolic side effects in people with treatment-resistant schizophrenia who are taking clozapine.

  Recruiting Faculty of Medicine, Sousse · Sousse · NCT07817069

• Evenamide added to standard antipsychotic treatment for treatment-resistant schizophrenia

  This 12-week randomized, double-blind test will see if adding evenamide (15 mg twice daily) to a patient’s current antipsychotic helps adults with treatment-resistant schizophrenia improve symptoms compared with placebo.

  Recruiting at 10 sites Phase 3 Newron Pharmaceuticals SPA · Los Angeles, California and 18 other locations · NCT07184619

• Cognitive Behavioral Therapy for Sleep Issues in Schizophrenia

  This study tests if a special type of therapy for sleep problems can help people with schizophrenia who have trouble sleeping feel better and improve their overall quality of life.

  Recruiting Copenhagen University Hospital, Hvidovre · Glostrup, Denmark · NCT06749444

• Magnetic seizure therapy versus electroconvulsive therapy for treatment‑resistant schizophrenia

  This trial will test whether magnetic seizure therapy works as well as a specific form of electroconvulsive therapy for adults whose schizophrenia or schizoaffective disorder has not improved with medications.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Vancouver, British Columbia and 1 other locations · NCT06672588

• Using maintenance electroconvulsive therapy for treatment-resistant schizophrenia

  This study is testing if adding maintenance electroconvulsive therapy to clozapine can help people with treatment-resistant schizophrenia stay well longer and improve their quality of life.

  Recruiting Central Institute of Mental Health, Mannheim · Aachen and 13 other locations · NCT06456983

• Reducing auditory-verbal hallucinations in schizophrenia using brain stimulation

  This study is testing a new brain stimulation method to see if it can help people with schizophrenia who hear voices and haven't found relief with regular medications.

  Recruiting Centre Hospitalier St Anne · Paris · NCT06361160

• Neurofeedback treatment for schizophrenia patients with auditory hallucinations

  This study is testing if a special brain training method can help people with schizophrenia who hear voices feel better by changing how their brain works.

  Recruiting Boston VA Research Institute, Inc. · Brockton, Massachusetts · NCT05299749

• Evaluation of the redevelopment of Ireland's National Forensic Mental Health Service

  This study is testing how moving to a new 170-bed mental health hospital in Ireland affects the recovery and care of patients with mental health issues involved in the justice system.

  Recruiting Health Service Executive, Ireland · Dublin · NCT05074732

Related topics

Quick answers

How many Treatment-resistant Schizophrenia clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (2 trials), France (1 trial), Denmark (1 trial), Canada (1 trial), Argentina (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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