Condition

Stage IV Bladder Cancer AJCC v8 clinical trials and research

• 6Clinical trials
• 2Countries

Newest Stage IV Bladder Cancer AJCC v8 clinical trials

All recruiting trials (6)

• Enfortumab Vedotin, Pembrolizumab, and Quemliclustat for unresectable or metastatic urothelial cancer

  This trial tests a three-drug combination to see if it can safely treat unresectable or metastatic urothelial cancer in adults.

  Recruiting Phase 1/2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT07667335

• Consolidative therapy after initial response in advanced bladder cancer

  This pilot trial tests adding radiation or surgery after a good response to EV + pembrolizumab in unresectable or oligometastatic muscle-invasive bladder cancer to see if residual disease can be eliminated or delayed from growing.

  Recruiting Phase 1/2 University of Washington · Seattle, Washington · NCT07579195

• Combination of Enfortumab Vedotin and Pembrolizumab with Surgery for Advanced Bladder Cancer

  This study is testing if a combination of two medications, enfortumab vedotin and pembrolizumab, can help people with advanced bladder cancer before they have surgery.

  Recruiting Phase 4 Mayo Clinic · Rochester, Minnesota · NCT06764095

• Using pemetrexed to treat metastatic bladder cancer and other solid tumors with specific gene mutations

  This study is testing if the drug pemetrexed can help people with advanced bladder cancer and other solid tumors that have certain gene mutations.

  Recruiting at 2 sites Phase 2 Northwestern University · Chicago, Illinois and 1 other locations · NCT06630416

• Combination treatment for advanced bladder cancer

  This study is testing a new combination of two treatments for people with advanced bladder cancer to see if it helps them respond better and live longer.

  Recruiting at 4 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT05756569

• Combining immunotherapy and targeted therapy for rare bladder tumors

  This study is testing a new combination of treatments for people with rare bladder tumors that have spread, to see if it helps them live longer and feel better.

  Recruiting at 222 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 581 other locations · NCT03866382

Related topics

Quick answers

How many Stage IV Bladder Cancer AJCC v8 clinical trials are recruiting right now?

6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (6 trials), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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