Condition
MTAP Deletion clinical trials and research
As of November 12, 2026, Find a Trial lists 3 MTAP Deletion clinical trials that are recruiting, at sites in 3 countries (most in United States (2), Australia (1), Taiwan (1)). By phase: Phase 1/2 (1), Phase 2 (1), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 3Countries
Newest MTAP Deletion clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| PEP08 for adults with advanced MTAP‑deleted solid tumors | Phase 1 | Wentworthville, New South Wales and 3 other locations | Recruiting | May 15, 2025 |
| TNG462 combined with RAS inhibitors or chemotherapy for MTAP‑loss pancreatic and RAS‑mutant lung cancer | Phase 1/2 | Scottsdale, Arizona and 17 other locations | Recruiting | Apr 10, 2025 |
| Using pemetrexed to treat metastatic bladder cancer and other solid tumors with specific gene mutations | Phase 2 | Chicago, Illinois and 1 other locations | Recruiting | Oct 8, 2024 |
All recruiting trials (3)
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PEP08 for adults with advanced MTAP‑deleted solid tumors
This trial will test whether PEP08, given alone or with another cancer drug, is safe and shows signs of benefit in adults with advanced or metastatic solid tumors that have MTAP deletion.
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TNG462 combined with RAS inhibitors or chemotherapy for MTAP‑loss pancreatic and RAS‑mutant lung cancer
This trial will test whether taking oral TNG462 together with RAS inhibitors or standard chemotherapy is safe and helps people with MTAP‑loss pancreatic cancer or RAS‑mutant non‑small cell lung cancer.
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Using pemetrexed to treat metastatic bladder cancer and other solid tumors with specific gene mutations
This study is testing if the drug pemetrexed can help people with advanced bladder cancer and other solid tumors that have certain gene mutations.
Related topics
Quick answers
How many MTAP Deletion clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (2 trials), Australia (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.