Condition
Secondary Central Nervous System Lymphoma (SCNSL) clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Secondary Central Nervous System Lymphoma (SCNSL) clinical trials that are recruiting, at sites in 9 countries (most in United States (2), China (1), France (1)). By phase: Phase 1 (2), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 9Countries
Newest Secondary Central Nervous System Lymphoma (SCNSL) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| PD‑1 blocker with rituximab, high‑dose methotrexate, and orelabrutinib for newly diagnosed primary or secondary CNS lymphoma | Phase 2 | Nanjing, Jiangsu | Recruiting | Feb 13, 2026 |
| Epcoritamab plus ibrutinib for central nervous system lymphoma | Phase 1 | Basking Ridge, New Jersey and 7 other locations | Recruiting | Jul 24, 2025 |
| Evaluating NX-5948 for advanced B-cell cancers | Phase 1 | Duarte, California and 61 other locations | Recruiting | Nov 23, 2021 |
All recruiting trials (3)
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PD‑1 blocker with rituximab, high‑dose methotrexate, and orelabrutinib for newly diagnosed primary or secondary CNS lymphoma
This trial will test whether combining a PD‑1 blocker with rituximab, high‑dose methotrexate, and orelabrutinib helps people with newly diagnosed primary or secondary central nervous system diffuse large B‑cell lymphoma.
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Epcoritamab plus ibrutinib for central nervous system lymphoma
This trial tests whether combining epcoritamab and ibrutinib is safe and tolerable for adults with relapsed or refractory primary or secondary central nervous system lymphoma.
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Evaluating NX-5948 for advanced B-cell cancers
This study is testing a new drug called NX-5948 to see if it can safely help adults with tough-to-treat B-cell cancers feel better.
Related topics
Quick answers
How many Secondary Central Nervous System Lymphoma (SCNSL) clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 9 countries. The most sites are in United States (2 trials), China (1 trial), France (1 trial), Italy (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.