Condition
Secondary Progressive Multiple Sclerosis clinical trials and research
Research outlook What's coming for Multiple sclerosis: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 3 Secondary Progressive Multiple Sclerosis clinical trials that are recruiting, at sites in 21 countries (most in United States (2), United Kingdom (1), Australia (1)). By phase: Phase 3 (2), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 21Countries
Newest Secondary Progressive Multiple Sclerosis clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Orelabrutinib for non-active secondary progressive multiple sclerosis | Phase 3 | Phoenix, Arizona and 89 other locations | Recruiting | Dec 23, 2025 |
| Comparing stem cell transplant to best available therapy for treatment-resistant multiple sclerosis | Phase 3 | Palo Alto, California and 22 other locations | Recruiting | Aug 7, 2019 |
| Investigating the safety of ixazomib for treating multiple sclerosis | Phase 1 | London, Greater London | Recruiting | Dec 21, 2018 |
All recruiting trials (3)
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Orelabrutinib for non-active secondary progressive multiple sclerosis
This trial will try daily orelabrutinib versus placebo in adults with non-active secondary progressive multiple sclerosis to see if it slows disability progression.
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Comparing stem cell transplant to best available therapy for treatment-resistant multiple sclerosis
This study is testing if a stem cell transplant can help people with treatment-resistant multiple sclerosis feel better compared to the best available therapies.
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Investigating the safety of ixazomib for treating multiple sclerosis
This study is testing if ixazomib can safely help people with multiple sclerosis by reducing certain markers in their spinal fluid.
Related topics
Quick answers
How many Secondary Progressive Multiple Sclerosis clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 21 countries. The most sites are in United States (2 trials), United Kingdom (1 trial), Australia (1 trial), Belgium (1 trial), Bulgaria (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.