Condition
Patent Foramen Ovale (PFO) clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Patent Foramen Ovale (PFO) clinical trials that are recruiting, at sites in 3 countries (most in United States (2), China (1), Taiwan (1)). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 3Countries
Newest Patent Foramen Ovale (PFO) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Pulmonary embolism with right-to-left heart or lung shunts | — | Boston, Massachusetts | Recruiting | Apr 9, 2026 |
| PFO closure versus blood thinners to prevent repeat stroke in older adults | — | Taichung and 2 other locations | Recruiting | Mar 18, 2026 |
| Non-invasive detection of right-to-left heart shunts | — | La Jolla, California | Recruiting | Feb 19, 2026 |
| Investigating cerebral microembolization in patients with PFO closure | — | Beijing, Beijing Municipality | Recruiting | Apr 4, 2024 |
All recruiting trials (4)
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Pulmonary embolism with right-to-left heart or lung shunts
This project will see if people with an acute pulmonary embolism who also have a right-to-left shunt (like a PFO or ASD) are more likely to have a stroke than PE patients without a shunt.
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PFO closure versus blood thinners to prevent repeat stroke in older adults
This study will test whether closing a patent foramen ovale or taking direct oral anticoagulants better prevents repeat strokes in adults over 60 with PFO-related embolic stroke.
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Non-invasive detection of right-to-left heart shunts
This project will test if a new handheld, battery-powered ultrasound device can detect right-to-left heart shunts in patients having a TEE with a bubble study for suspected PFO.
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Investigating cerebral microembolization in patients with PFO closure
This study is trying to see if patients with a heart condition called PFO who undergo a closure procedure experience tiny blood clots in the brain and how these might relate to existing clots in the heart.
Related topics
Quick answers
How many Patent Foramen Ovale (PFO) clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (2 trials), China (1 trial), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.