Non-invasive detection of right-to-left heart shunts

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational protocol compares a novel battery-powered, non-invasive handheld ultrasound device with transesophageal echocardiography (TEE) with bubble study for detecting right-to-left cardiac shunts consistent with patent foramen ovale. Eligible participants are patients already scheduled for a clinically indicated TEE with contrast at Scripps Memorial Hospital La Jolla. Operators will perform point-of-care transthoracic contrast-enhanced ultrasound with the handheld device during the clinical encounter and record findings blinded to the TEE results. The study will analyze device sensitivity and concordance with the TEE bubble study to determine its ability to detect shunts.

Why it matters

Who can join: the full rules

Undergoing clinically indicated TEE with bubble study for the detection of a PFO

Where it's running

• Scripps Memorial Hospital La Jolla
  La Jolla, California, United States Recruiting

Study contacts

• Study coordinator: Matthew J Price, MD
• Email: price.matthew@scrippshealth.org
• Phone: 858-824-5269

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulmonary embolism with right-to-left heart or lung shunts

  This project will see if people with an acute pulmonary embolism who also have a right-to-left shunt (like a PFO or ASD) are more likely to have a stroke than PE patients without a shunt.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT07519876

• PFO closure versus blood thinners to prevent repeat stroke in older adults

  This study will test whether closing a patent foramen ovale or taking direct oral anticoagulants better prevents repeat strokes in adults over 60 with PFO-related embolic stroke.

  Recruiting at 3 sites Taichung Veterans General Hospital · Taichung and 2 other locations · NCT07479147

• Investigating cerebral microembolization in patients with PFO closure

  This study is trying to see if patients with a heart condition called PFO who undergo a closure procedure experience tiny blood clots in the brain and how these might relate to existing clots in the heart.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT06347276

• P3 Occluder System for closing a heart opening (PFO) after stroke

  We are testing the P3 Occluder System to see if it safely and effectively closes a patent foramen ovale in adults who had a stroke related to their heart opening.

  Recruiting Recross Cardio, Inc. · Belgrade · NCT07698951

• Non-invasive detection of right-to-left shunts with the SONAS headband

  This will test whether the SONAS headband can find right-to-left shunts in adults with hereditary hemorrhagic telangiectasia (HHT) who are already having a bubble heart ultrasound (TTCE).

  Recruiting St. Antonius Hospital · Nieuwegein, Utrecht · NCT07414446

• Percutaneous repair of the atrial septum using the P3 Occluder System for PFO closure

  This trial tests the P3 Occluder System to close a patent foramen ovale (PFO) in adults 18–65 who have had a stroke that may be linked to their PFO.

  Recruiting at 5 sites Recross Cardio, Inc. · Los Angeles, California and 4 other locations · NCT07172464

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.