Condition
Methotrexate clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Methotrexate clinical trials that are recruiting, at sites in 9 countries (most in France (2), Australia (1), Brazil (1)). By phase: Phase 2 (2), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 9Countries
Newest Methotrexate clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Methotrexate for knee osteoarthritis with ultrasound-proven synovitis | Phase 2 | Dhaka, Dhaka Division | Recruiting | Sep 8, 2025 |
| Resveratrol added to usual treatment for moderate-to-high rheumatoid arthritis | — | Cairo | Recruiting | Jul 28, 2025 |
| Using durvalumab with chemotherapy for muscle-invasive bladder cancer | Phase 2 | Chermside and 58 other locations | Recruiting | May 7, 2025 |
| Comparing Azathioprine and Methotrexate with Adalimumab for Crohn's Disease | Phase 3 | Amiens | Recruiting | Sep 10, 2021 |
All recruiting trials (4)
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Methotrexate for knee osteoarthritis with ultrasound-proven synovitis
This randomized trial will try methotrexate versus placebo to see if it reduces pain and inflamed lining (synovitis) in people aged 40–70 with knee osteoarthritis confirmed by ultrasound.
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Resveratrol added to usual treatment for moderate-to-high rheumatoid arthritis
This will see if giving adults with moderate-to-high rheumatoid arthritis 1 g of resveratrol daily alongside their usual medicines for three months reduces inflammation, disease activity, and improves quality of life.
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Using durvalumab with chemotherapy for muscle-invasive bladder cancer
This study is testing if adding a new immune therapy called durvalumab to standard chemotherapy can help people with muscle-invasive bladder cancer before they have surgery.
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Comparing Azathioprine and Methotrexate with Adalimumab for Crohn's Disease
This study is testing whether adding azathioprine or methotrexate to adalimumab helps people with Crohn's disease who haven't improved with other treatments.
Related topics
Quick answers
How many Methotrexate clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 9 countries. The most sites are in France (2 trials), Australia (1 trial), Brazil (1 trial), Canada (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.