Condition

Metastatic Colorectal Adenocarcinoma clinical trials and research

• 9Clinical trials
• 5Countries

Newest Metastatic Colorectal Adenocarcinoma clinical trials

All recruiting trials (9)

• Dual-target CAR-NK therapy for advanced colorectal cancer

  This trial tests an off-the-shelf CAR-NK cell treatment that targets two colorectal cancer markers in adults with unresectable or metastatic disease.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07589517

• New oral medicine PF-08032562 for advanced or metastatic breast and colorectal cancer

  This trial will try an oral medicine called PF-08032562, given alone or with other cancer drugs, in adults with advanced or metastatic breast or colorectal cancer.

  Recruiting at 13 sites Phase 1 Pfizer · Duarte, California and 16 other locations · NCT07318805

• Pidnarulex plus cemiplimab for refractory microsatellite-stable colorectal cancer.

  This tests whether combining pidnarulex with cemiplimab is safe and can help people whose microsatellite-stable colorectal cancer has stopped responding to standard treatments.

  Recruiting at 7 sites Phase 1/2 National Cancer Institute (NCI) · Aurora, Colorado and 6 other locations · NCT07147231

• Amplitude-modulated radiofrequency therapy plus fruquintinib for refractory metastatic colorectal cancer

  This trial will test whether adding amplitude-modulated radiofrequency electromagnetic fields to the drug fruquintinib helps people with metastatic colorectal cancer that has not responded to standard treatments.

  Recruiting at 9 sites Phase 2 Barbara Ann Karmanos Cancer Institute · Bay City, Michigan and 8 other locations · NCT07130903

• Combining CA-4948 with chemotherapy for metastatic colorectal cancer

  This study is testing a new drug called CA-4948 combined with chemotherapy to see if it can safely help people with metastatic colorectal cancer.

  Recruiting at 13 sites Phase 1 National Cancer Institute (NCI) · Gainesville, Florida and 12 other locations · NCT06696768

• Combining botensilimab, balstilimab, a fasting mimicking diet, and vitamin C for KRAS-mutant metastatic colorectal cancer

  This study is testing if combining two new antibodies with a special diet and vitamin C can help people with KRAS-mutant metastatic colorectal cancer live longer and feel better.

  Recruiting at 3 sites Phase 1 University of Southern California · Fullerton, California and 2 other locations · NCT06336902

• Combining ZEN003694 with standard chemotherapy for advanced colorectal cancer

  This study is testing if a new drug called ZEN003694 can safely improve the effects of standard chemotherapy for people with advanced colorectal cancer that hasn't responded to other treatments.

  Recruiting at 10 sites Phase 1 National Cancer Institute (NCI) · Costa Mesa, California and 15 other locations · NCT06102902

• Combining total ablative therapy with standard treatment for limited metastatic colorectal cancer

  This study is testing if adding a special type of radiation therapy and possible surgery to standard chemotherapy can help people with limited metastatic colorectal cancer live longer and stay healthier.

  Recruiting at 172 sites Phase 2 Alliance for Clinical Trials in Oncology · Kingman, Arizona and 194 other locations · NCT05673148

• Combining trifluridine/tipiracil with talazoparib for advanced colorectal or gastroesophageal cancer

  This study is testing a new combination of two cancer drugs to see if they can safely help people with advanced colorectal or gastroesophageal cancer.

  Recruiting Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT04511039

Related topics

Quick answers

How many Metastatic Colorectal Adenocarcinoma clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (8 trials), France (1 trial), Spain (1 trial), China (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 1/2: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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