Condition

GastroEsophageal Cancer clinical trials and research

• 14Clinical trials
• 4NIH research projects
• 11Countries

Newest GastroEsophageal Cancer clinical trials

All recruiting trials (14)

• MGC030 in adults with advanced solid tumors

  This trial tests MGC030 in adults with advanced urothelial, gastric/GEJ, esophageal, colorectal, gastric, pancreatic, or GEJ cancers to see if it is safe and whether it can shrink tumors or stop growth.

  Recruiting Phase 1 MacroGenics · Lake Success, New York · NCT07822399

• First-in-human dose study of DA-3501 for CLDN18.2-positive stomach, GEJ cancer, and pancreatic cancer

  A first-in-human study tests DA-3501 in adults with CLDN18.2-positive advanced stomach/GEJ cancer or pancreatic cancer to find a safe, effective dose.

  Recruiting at 3 sites Phase 1 Dong-A ST Co., Ltd. · Seongnam, Bundang and 2 other locations · NCT07481357

• Collecting blood and leftover tumor tissue to test molecular residual disease (MRD) detection

  This project will test whether blood and leftover tumor tissue from adults with certain solid tumors can be used with Natera's MRD blood tests to find tiny amounts of cancer (ctDNA) after treatment.

  Recruiting Natera, Inc. · Austin, Texas · NCT07318051

• Pulsed low-dose-rate radiation plus chemotherapy versus standard chemoradiation for esophageal cancer

  This trial will test whether delivering radiation as pulsed low-dose-rate together with chemotherapy reduces serious esophagitis compared with standard chemoradiation in adults with locally advanced esophageal adenocarcinoma.

  Recruiting Phase 2 Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06906887

• Evaluating zanidatamab for HER2-expressing tumors

  This study is testing a new drug called zanidatamab to see if it can help people with certain types of cancer that have high levels of HER2 and who have already tried other treatments without success.

  Recruiting at 30 sites Phase 2 Jazz Pharmaceuticals · Prescott, Arizona and 41 other locations · NCT06695845

• Support program for patients with gastroesophageal cancer

  This study tests if a special support program with nutrition help can improve the health of patients with gastroesophageal cancer compared to regular care during their treatment.

  Recruiting at 2 sites H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida and 1 other locations · NCT06497569

• Combining PD-1 antibody and chemotherapy followed by surgery for limited metastatic gastric cancer

  This study tests if combining immunotherapy and chemotherapy with surgery can help people with limited metastatic gastric cancer live longer and feel better compared to just using the treatments without surgery.

  Recruiting Phase 2 Shanghai Zhongshan Hospital · Shanghai, Shanghai City and 1 other locations · NCT06468280

• Reducing dosing frequency of immune checkpoint inhibitors in advanced cancers

  This study is testing if giving immune checkpoint inhibitors less often can still help people with advanced cancers feel better while making treatment easier and cheaper.

  Recruiting Phase 2 National University Hospital, Singapore · Singapore · NCT06422403

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• Impact of exercise and diet on quality of life for patients with incurable esophageal and stomach cancer

  This study is testing if a program that combines exercise and better nutrition can improve the quality of life for patients with incurable esophageal and stomach cancer after their first treatment hasn't worked.

  Recruiting at 18 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland and 21 other locations · NCT06138223

• Total neoadjuvant chemotherapy for advanced gastric and gastroesophageal cancer

  This study is testing two different chemotherapy plans for people with advanced stomach cancer to see which one helps them better tolerate treatment and successfully have surgery.

  Recruiting at 2 sites Phase 2/3 Ukrainian Society of Clinical Oncology · Vilnius and 1 other locations · NCT06028737

• Understanding the immune environment in gastroesophageal cancer

  This study looks at how the immune system reacts in patients with stomach and gastroesophageal junction cancer who are receiving chemotherapy to see if it can help improve their treatment outcomes.

  Recruiting Centre Leon Berard · Lyon · NCT05644431

• Comparing minimally invasive surgeries for stomach cancer

  This study is testing whether a less invasive stomach surgery helps people with stomach cancer feel better and maintain their appetite compared to a more extensive surgery.

  Recruiting at 3 sites M.D. Anderson Cancer Center · Rochester, Minnesota and 3 other locations · NCT05205343

• Combining chemotherapy and immunotherapy for esophageal cancer treatment

  This study is testing if combining immunotherapy with chemotherapy can help improve survival for patients with esophageal cancer who had surgery but are at high risk of their cancer coming back.

  Recruiting The Second Hospital of Shandong University · Jinan, Shandong · NCT04688801

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting FGFR Alterations in Gastroesophageal Cancer

  A study aiming to improve treatment for stomach and esophagus cancers by targeting FGFR2 alterations, including combinations with antibody therapies.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11384543

• FGFR-targeted treatments for stomach and esophagus cancer

  Developing new drug combinations that target FGFR2 changes for people with gastroesophageal (stomach and esophagus) cancer.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11140393

• Combining immunotherapy to improve treatment for metastatic gastroesophageal cancer

  This study is exploring a new way to treat advanced stomach and esophagus cancer by using a mix of immune therapies to help your body fight the cancer better, and it's designed for patients looking for improved treatment options.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11001181

• Targeting specific changes in a cancer-related gene in stomach and esophagus cancer

  This study is looking at new ways to treat stomach and esophagus cancer for patients with certain changes in their FGFR2 gene, by combining regular chemotherapy with special targeted treatments to help improve their chances of recovery.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10999105

Related topics

Quick answers

How many GastroEsophageal Cancer clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (7 trials), South Korea (3 trials), China (2 trials), Netherlands (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 2, Phase 1/2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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