Combining immunotherapy to improve treatment for metastatic gastroesophageal cancer
Official title: Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer
Funded at Mayo Clinic Rochester · NIH-11001181 · Data updated 2026-11-12
This study is exploring a new way to treat advanced stomach and esophagus cancer by using a mix of immune therapies to help your body fight the cancer better, and it's designed for patients looking for improved treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $627,404 |
| NIH project number | 5R01CA248147-05 |
| Project ID | NIH-11001181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic gastroesophageal adenocarcinoma who have not responded adequately to standard treatments.
✕Less likely to help
Patients with early-stage gastroesophageal cancer or those who have already received extensive prior treatments may not benefit from this research.
What this research studies
This research investigates a new approach to treating metastatic gastroesophageal adenocarcinoma by combining different immunotherapy treatments. The goal is to enhance the effectiveness of existing therapies, particularly by using anti-PD-1 antibodies alongside anti-angiogenesis therapy and immunomodulatory chemotherapy in a specific sequence. This method aims to improve patient outcomes by disrupting the tumor's immunosuppressive environment and boosting the body's immune response against the cancer. Patients will be monitored for both local and systemic immune responses during the treatment.
Why it matters
Potential benefit: If successful, this research could provide more effective treatment options for patients with metastatic gastroesophageal cancer, potentially improving survival rates.
How similar studies have gone: Other research has shown promising results with similar immunotherapy combination approaches, indicating potential for success in this area.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Yoon, Harry H — Mayo Clinic Rochester
- Study coordinator: Yoon, Harry H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.