Drug or treatment

Zanidatamab clinical trials

• 10Clinical trials
• 30Countries

Newest trials

All recruiting trials (10)

• Zanidatamab given before surgery for HER2-positive colon or rectal cancer

  This tests whether giving zanidatamab before surgery helps adults with HER2-positive, RAS‑wildtype colon or rectal cancer who are planned for curative treatment.

  Recruiting at 4 sites Phase 2 Emory University · Atlanta, Georgia and 3 other locations · NCT07405476

• Neoadjuvant zanidatamab and tislelizumab with chemotherapy to try to preserve the bladder in HER2-positive muscle-invasive bladder cancer

  This study tests whether giving zanidatamab and tislelizumab with chemotherapy before surgery can allow people with HER2-positive muscle-invasive bladder cancer to keep their bladder.

  Recruiting at 12 sites Phase 2 Fujian Medical University Union Hospital · Fuzhou, Fujian and 11 other locations · NCT07296705

• Zanidatamab for solid tumors with HER2 changes

  This study will try zanidatamab, an anti-HER2 drug, in adults with advanced endometrial, colorectal, head and neck, sarcoma, or non-small cell lung cancer whose tumors have specific HER2 changes.

  Recruiting at 2 sites Phase 2 Unicancer · Angers and 3 other locations · NCT07192068

• Zanidatamab with pembrolizumab and chemotherapy for HER2- and PD-L1-positive metastatic gastroesophageal adenocarcinoma

  This trial tests whether adding zanidatamab to pembrolizumab plus chemotherapy helps people with untreated HER2- and PD-L1-positive metastatic gastroesophageal adenocarcinoma.

  Recruiting at 14 sites Phase 2 Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest · Berlin and 19 other locations · NCT07176312

• Neoadjuvant zanidatamab plus chemotherapy for HER2-positive early breast cancer

  This study will test if adding zanidatamab to chemotherapy given before surgery helps people with HER2-positive early-stage breast cancer.

  Recruiting at 53 sites Phase 2 Jazz Pharmaceuticals · Long Beach, California and 52 other locations · NCT07102381

• Evaluating zanidatamab for HER2-expressing tumors

  This study is testing a new drug called zanidatamab to see if it can help people with certain types of cancer that have high levels of HER2 and who have already tried other treatments without success.

  Recruiting at 30 sites Phase 2 Jazz Pharmaceuticals · Prescott, Arizona and 41 other locations · NCT06695845

• Comparing zanidatamab and trastuzumab for metastatic HER2-positive breast cancer treatment

  This study is testing whether a new treatment called zanidatamab, used with chemotherapy, works better than the standard treatment trastuzumab with chemotherapy for people with advanced HER2-positive breast cancer who haven't responded well to previous therapies.

  Recruiting at 163 sites Phase 3 Jazz Pharmaceuticals · Phoenix, Arizona and 165 other locations · NCT06435429

• Zanidatamab combined with standard therapy for advanced HER2-positive biliary tract cancer

  This study is testing if a new treatment combining Zanidatamab with standard chemotherapy can help people with advanced HER2-positive biliary tract cancer feel better and live longer.

  Recruiting at 69 sites Phase 3 Jazz Pharmaceuticals · Duarte, California and 184 other locations · NCT06282575

• Combining zanidatamab with standard treatment for advanced HER2 positive gastroesophageal cancer

  This study is testing if adding a new drug called zanidatamab to standard treatments can help people with advanced HER2 positive gastroesophageal cancer live longer without their cancer getting worse.

  Recruiting at 18 sites Phase 2 Canadian Cancer Trials Group · Calgary, Alberta and 17 other locations · NCT06043427

• Evaluating zanidatamab in early stage HER2-positive breast cancer

  This study is testing if zanidatamab can help people with early stage HER2-positive breast cancer by seeing how well it shrinks tumors and checking for any side effects.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05035836

Quick answers

How many clinical trials of Zanidatamab are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 30 countries. The most sites are in United States (6 trials), Germany (4 trials), Spain (4 trials), Italy (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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