Condition

Extensive-stage Small-cell Lung Cancer clinical trials and research

• 25Clinical trials
• 31Countries

Newest Extensive-stage Small-cell Lung Cancer clinical trials

All recruiting trials (25)

• QLC5508 plus QL2107 vs tislelizumab plus platinum chemotherapy as first treatment for extensive-stage small cell lung cancer

  This phase 3 trial tests whether QLC5508 with QL2107 works better than tislelizumab with platinum chemotherapy for adults with untreated extensive-stage small cell lung cancer.

  Recruiting Phase 3 Qilu Pharmaceutical Co., Ltd. · Shanghai · NCT07802821

• BL-M14D1 with Atezolizumab for extensive-stage small cell lung cancer

  This phase 2 trial tests whether adding BL-M14D1 to atezolizumab helps people with extensive-stage small cell lung cancer live longer or well enough to continue treatment.

  Recruiting Phase 2 Biokin (Shanghai) Biopharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT07654400

• Tislelizumab use in European patients with NSCLC or ES-SCLC in routine care

  This study looks at how tislelizumab is used in real-world European patients with advanced NSCLC or extensive-stage SCLC and what outcomes are seen in everyday clinical practice.

  Recruiting at 6 sites BeOne Medicines · Córdoba and 5 other locations · NCT07652736

• Autologous B7-H3 CAR T Cells in Advanced Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

  This study tests a patient’s own B7-H3 CAR T cells to see if they can help people 18 and older whose small cell lung cancer or EPNEC has come back or hasn’t responded to prior treatment.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07509034

• BL-B01D1 plus tislelizumab vs platinum-based chemo plus tislelizumab as first-line treatment for extensive-stage small cell lung cancer

  This trial tests whether adding BL-B01D1 to tislelizumab works better than platinum-containing chemotherapy with tislelizumab for adults with extensive-stage small cell lung cancer.

  Recruiting at 2 sites Phase 3 Sichuan Baili Pharmaceutical Co., Ltd. · Zhengzhou, Henan and 1 other locations · NCT07502300

• Lurbinectedin plus durvalumab for extensive-stage small-cell lung cancer after initial treatment

  This study tests whether adding durvalumab to lurbinectedin as maintenance after initial therapy helps people whose ES-SCLC has not progressed.

  Recruiting at 6 sites Phase 2 Jazz Pharmaceuticals · Los Angeles, California and 5 other locations · NCT07459634

• Using T-cell receptor patterns to predict response to first-line tislelizumab plus chemotherapy in extensive-stage small-cell lung cancer

  This will test whether patterns in patients' T-cell receptors can predict how well first-line tislelizumab plus chemotherapy works for people with extensive-stage small-cell lung cancer.

  Recruiting Henan Cancer Hospital · Zhengzhou, Henan · NCT07244016

• Phase 1 ALPS12 treatment for extensive-stage small cell lung cancer

  This trial tests a new drug called ALPS12, given alone or with obinutuzumab, in adults with extensive-stage small cell lung cancer that has returned after prior therapy.

  Recruiting at 6 sites Phase 1 Chugai Pharmaceutical · Hong Kong and 5 other locations · NCT07107490

• First-line immunotherapy plus chemotherapy in extensive-stage small cell lung cancer

  This study tests whether adding Tafolecimab and Sintilimab to standard chemotherapy can help people with extensive-stage small cell lung cancer.

  Recruiting at 4 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Changsha, Hunan and 4 other locations · NCT07061535

• Tarlatamab plus AB248 for extensive-stage small cell lung cancer (DeLLphi-311)

  This trial tests whether combining tarlatamab with AB248 is safe and tolerable for adults whose extensive-stage small cell lung cancer has progressed after prior therapy.

  Recruiting at 18 sites Phase 1 Amgen · Gilbert, Arizona and 18 other locations · NCT07037758

• Testing valemetostat with atezolizumab for lung cancer treatment

  This study is testing a new combination of medications, valemetostat and atezolizumab, to see if it can safely help people with extensive-stage small cell lung cancer who have had some success with earlier treatments.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06807632

• Treatment for advanced HR+/HER2- breast cancer and other solid tumors

  This study is testing a new treatment called ECI830, alone and with other medications, to see if it helps people with advanced hormone receptor-positive breast cancer and certain other solid tumors.

  Recruiting at 33 sites Phase 1/2 Novartis · Los Angeles, California and 32 other locations · NCT06726148

• Investigating BNT327 with chemotherapy for untreated small-cell lung cancer

  This study is testing whether a new treatment called BNT327, combined with standard chemotherapy, can help people with untreated extensive-stage small-cell lung cancer feel better compared to another treatment option.

  Recruiting at 188 sites Phase 3 BioNTech SE · Tucson, Arizona and 224 other locations · NCT06712355

• Comparing two treatments for extensive-stage small cell lung cancer

  This study is testing a new treatment combination for extensive-stage small cell lung cancer to see if it works better and is safer than the standard treatment.

  Recruiting at 18 sites Phase 3 Bristol-Myers Squibb · Daphne, Alabama and 182 other locations · NCT06646276

• Tarlatamab treatment for extensive stage small cell lung cancer

  This study is testing a new treatment called tarlatamab for people with extensive stage small cell lung cancer who haven't had success with previous chemotherapy to see if it helps them feel better.

  Recruiting at 31 sites Phase 1 Amgen · Los Angeles, California and 30 other locations · NCT06598306

• Combining Tislelizumab with chemotherapy and radiotherapy for extensive-stage small-cell lung cancer

  This study is testing if combining a new drug called Tislelizumab with chemotherapy and radiation can help people with extensive-stage small-cell lung cancer feel better and improve their health.

  Recruiting at 6 sites Phase 2 Second Hospital of Shanxi Medical University · Jincheng, Shanxi and 5 other locations · NCT06536868

• Maintenance lurbinectedin with serplulimab after first-line therapy for extensive-stage small cell lung cancer

  This study tests whether continuing lurbinectedin with serplulimab after initial treatment helps people with extensive-stage small cell lung cancer stay disease control.

  Recruiting Phase 2 Guangzhou Institute of Respiratory Disease · Guangzhou, Guangdong · NCT06497530

• Combination therapy for extensive-stage small cell lung cancer

  This study is testing a new combination treatment for people with extensive-stage small cell lung cancer to see how well it works and what side effects it might have.

  Recruiting Phase 2 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06437509

• Evaluating a new treatment for extensive stage-small cell lung cancer

  This study is testing a new treatment combining ifinatamab deruxtecan and atezolizumab, with or without carboplatin, to see if it can help people with extensive stage-small cell lung cancer feel better and improve their treatment results.

  Recruiting at 55 sites Phase 1/2 Daiichi Sankyo · Birmingham, Alabama and 57 other locations · NCT06362252

• Combining durvalumab with radiochemotherapy and stereotactic radiotherapy for extensive-stage small-cell lung cancer

  This study is testing if adding the immunotherapy drug durvalumab to radiochemotherapy and targeted radiation can help people with extensive-stage small-cell lung cancer feel better and manage their disease.

  Recruiting at 5 sites Phase 2 Universität des Saarlandes · Augsburg, Bavaria and 4 other locations · NCT06223711

• Combining low-dose radiotherapy with sugemalimab, chemotherapy, and olaparib for treating advanced small-cell lung cancer

  This study is testing a new treatment plan that combines low-dose radiation, a drug called sugemalimab, chemotherapy, and another drug called olaparib to see if it helps people with advanced small-cell lung cancer.

  Recruiting Phase 1/2 Sichuan University · Chengdu, Sichuan · NCT06217757

• Combination treatment for extensive stage small cell lung cancer

  This study is testing a new combination treatment for people with extensive stage small cell lung cancer to see if it helps them live longer and feel better.

  Recruiting at 4 sites Phase 2 Hoosier Cancer Research Network · Indianapolis, Indiana and 3 other locations · NCT05903092

• Combining Bevacizumab with Chemoimmunotherapy for Advanced Lung Cancer with Liver Metastases

  This study is testing whether adding a drug called bevacizumab to a combination of chemotherapy and another treatment can help people with advanced lung cancer that has spread to the liver live longer and feel better.

  Recruiting at 3 sites Phase 2 Cedars-Sinai Medical Center · Los Angeles, California and 2 other locations · NCT05588388

• Combining durvalumab with radiation for extensive-stage small cell lung cancer

  This study is testing if adding a new drug called durvalumab to radiation and chemotherapy can help people with extensive-stage small cell lung cancer live longer without their cancer getting worse.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois and 1 other locations · NCT05068232

• Comparing brain MRI surveillance to prophylactic cranial irradiation in small cell lung cancer patients

  This study is testing if regular brain MRIs alone can help small cell lung cancer patients just as much as a combination of brain MRIs and preventive radiation therapy.

  Recruiting at 41 sites European Organisation for Research and Treatment of Cancer - EORTC · Graz and 54 other locations · NCT04790253

Related topics

Quick answers

How many Extensive-stage Small-cell Lung Cancer clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in China (13 trials), United States (12 trials), Spain (7 trials), Japan (6 trials), France (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 5, Phase 3: 4, Phase 1/2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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