Condition

Extensive-stage Small Cell Lung Cancer (ES-SCLC) clinical trials and research

• 14Clinical trials
• 41Countries

Newest Extensive-stage Small Cell Lung Cancer (ES-SCLC) clinical trials

All recruiting trials (14)

• Metronomic oral paclitaxel with PD-1/PD-L1 inhibitor maintenance in advanced lung cancer

  This trial tests whether taking low, regular doses of oral paclitaxel plus a PD-1 or PD-L1 inhibitor as maintenance therapy can help people with advanced sqNSCLC or ES-SCLC who did not progress after first-line chemo-immunotherapy.

  Recruiting Phase 4 Anhui Provincial Cancer Hospital · Hefei, Anhui · NCT07744698

• DJI136 CAR-T therapy for extensive-stage small cell lung cancer

  Researchers are testing DJI136, a CAR-T cell therapy, to see if it can help adults with extensive-stage small cell lung cancer who have already tried standard treatments.

  Recruiting at 7 sites Phase 1/2 Novartis · Lexington, Kentucky and 6 other locations · NCT07564401

• Obrixtamig with atezolizumab, carboplatin, and etoposide for advanced small cell lung cancer

  This trial will test whether adding obrixtamig to atezolizumab plus carboplatin and etoposide helps people with extensive-stage small cell lung cancer live longer.

  Recruiting at 166 sites Phase 3 Boehringer Ingelheim · Mobile, Alabama and 241 other locations · NCT07472517

• Tislelizumab with chemotherapy followed by chest consolidation radiotherapy as first-line treatment for extensive-stage small cell lung cancer

  This trial will test whether adding the immunotherapy drug tislelizumab to standard chemotherapy followed by chest radiation helps people newly diagnosed with extensive-stage small cell lung cancer.

  Recruiting Phase 2 Chongqing University Cancer Hospital · Chongqing, Chongqing Municipality · NCT07425795

• Sacituzumab govitecan with atezolizumab or durvalumab as maintenance for extensive-stage small cell lung cancer

  This study tests whether adding sacituzumab govitecan to ongoing atezolizumab or durvalumab can better control tumors in adults with extensive-stage small cell lung cancer after initial platinum-based chemotherapy.

  Recruiting Phase 2 Henry Ford Health System · Detroit, Michigan · NCT07339059

• Ivonescimab combinations for first-line extensive-stage small cell lung cancer

  This test tries whether adding AK117 or cadonilimab to ivonescimab plus chemotherapy helps adults newly diagnosed with extensive-stage small cell lung cancer.

  Recruiting at 2 sites Phase 2 Akeso · Beijing, Beijing Municipality and 2 other locations · NCT07245446

• Iadademstat with SBRT and atezolizumab for extensive-stage small cell lung cancer

  This phase 1b test checks if adding iadademstat to stereotactic body radiotherapy (SBRT) and the immunotherapy atezolizumab is safe and helps control disease in adults with residual, recurrent, or progressive extensive-stage small cell lung cancer after platinum chemotherapy.

  Recruiting Phase 1 Yale University · New Haven, Connecticut · NCT07113691

• Blood microRNA markers to predict response to immunotherapy plus chemotherapy in extensive-stage small cell lung cancer

  This project will test whether small extracellular vesicle microRNAs in blood can predict which patients with extensive-stage small cell lung cancer will respond to first-line immunotherapy combined with chemotherapy.

  Recruiting Shanghai Chest Hospital of Shanghai Jiao Tong University · Shanghai · NCT07070011

• First-line immunotherapy plus chemotherapy in extensive-stage small cell lung cancer

  This study tests whether adding Tafolecimab and Sintilimab to standard chemotherapy can help people with extensive-stage small cell lung cancer.

  Recruiting at 4 sites Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Changsha, Hunan and 4 other locations · NCT07061535

• New treatment for advanced small cell lung cancer

  This study is testing a new combination of treatments for people with advanced small cell lung cancer who haven't had success with their first round of chemotherapy.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06853678

• Tislelizumab with platinum-etoposide chemotherapy and follow-up chest radiotherapy for extensive-stage small cell lung cancer

  This trial will test whether adding tislelizumab to first-line platinum-etoposide chemotherapy followed by planned chest radiotherapy helps people with newly diagnosed extensive-stage small cell lung cancer.

  Recruiting Phase 2 Anhui Provincial Cancer Hospital · Hefei, Anhui · NCT06838208

• Comparing sacituzumab govitecan to standard care for advanced small cell lung cancer

  This study is testing whether a new treatment called sacituzumab govitecan can help people with advanced small cell lung cancer live longer and feel better compared to standard care.

  Recruiting at 206 sites Phase 3 Gilead Sciences · Anchorage, Alaska and 218 other locations · NCT06801834

• Teniposide after prior therapy for c-Myc–driven extensive-stage small cell lung cancer

  This will try teniposide in people with extensive-stage small cell lung cancer driven by high c-Myc who have progressed after standard treatment.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT06758700

• Combining atezolizumab with chemotherapy for relapsed extensive-stage small cell lung cancer

  This study is testing if adding an immunotherapy drug called atezolizumab to standard chemotherapy can help people with relapsed extensive-stage small cell lung cancer live longer and feel better.

  Recruiting at 2 sites Phase 2 Gruppo Oncologico Italiano di Ricerca Clinica · Aviano (PN) and 24 other locations · NCT06663098

Related topics

Quick answers

How many Extensive-stage Small Cell Lung Cancer (ES-SCLC) clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 41 countries. The most sites are in China (10 trials), United States (4 trials), Italy (3 trials), Australia (3 trials), South Korea (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 3: 2, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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