Condition
Advanced HR+/HER2- Breast Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Advanced HR+/HER2- Breast Cancer clinical trials that are recruiting, at sites in 17 countries (most in Canada (3), France (3), Italy (3)). By phase: Phase 1/2 (2), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 17Countries
Newest Advanced HR+/HER2- Breast Cancer clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| IEV407 as a single agent or with endocrine therapy for advanced HR+/HER2- breast cancer | Phase 1 | New Haven, Connecticut and 11 other locations | Recruiting | May 22, 2026 |
| GVV858 alone or with fulvestrant or letrozole for HR+/HER2- breast cancer and other advanced tumors | Phase 1/2 | Atlanta, Georgia and 15 other locations | Recruiting | Dec 17, 2025 |
| Treatment for advanced HR+/HER2- breast cancer and other solid tumors | Phase 1/2 | Los Angeles, California and 32 other locations | Recruiting | Dec 10, 2024 |
All recruiting trials (3)
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IEV407 as a single agent or with endocrine therapy for advanced HR+/HER2- breast cancer
This study tests IEV407 by itself and with fulvestrant or letrozole to see if it is safe and shows signs of activity in adults with advanced HR+/HER2- breast cancer.
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GVV858 alone or with fulvestrant or letrozole for HR+/HER2- breast cancer and other advanced tumors
This trial tests whether GVV858 alone or with fulvestrant or letrozole can help adults with HR+/HER2- advanced breast cancer, CCNE1‑amplified solid tumors, or metastatic castration‑resistant prostate cancer.
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Treatment for advanced HR+/HER2- breast cancer and other solid tumors
This study is testing a new treatment called ECI830, alone and with other medications, to see if it helps people with advanced hormone receptor-positive breast cancer and certain other solid tumors.
Related topics
Quick answers
How many Advanced HR+/HER2- Breast Cancer clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 17 countries. The most sites are in Canada (3 trials), France (3 trials), Italy (3 trials), Japan (3 trials), Singapore (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.