Condition

ESCC clinical trials and research

• 10Clinical trials
• 1NIH research projects
• 1New in 30 days
• 3Countries

Newest ESCC clinical trials

All recruiting trials (10)

• Becotatug Vedotin with Immunotherapy and Radiotherapy in ESCC after first line

  This trial tests whether adding becotatug vedotin to an immune checkpoint inhibitor and targeted radiotherapy helps people with advanced ESCC after prior treatment.

  Recruiting Phase 2 The First Affiliated Hospital of Bengbu Medical University · Bengbu, Anhui · NCT07892833

• Lymphatic-sparing short-course radiotherapy with chemo-immunotherapy before surgery for locally advanced ESCC

  This study tests whether a short course of targeted radiotherapy combined with camrelizumab and nab-paclitaxel/carboplatin can shrink locally advanced esophageal squamous cell carcinoma enough for surgical removal.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guanzhou, Guangdong · NCT07808853

• Anlotinib plus Bemocizumab as neoadjuvant therapy for ESCC

  This trial tests whether giving anlotinib with bemocizumab before surgery can improve how completely the tumor is removed and prevent recurrence in people with resectable esophageal squamous cell carcinoma.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07627347

• Blood test combining cell-free and exosomal microRNAs for early detection of esophageal squamous cell carcinoma

  This project will try a blood test that measures cell-free and exosomal microRNAs to find early esophageal squamous cell carcinoma in adults using plasma or serum samples.

  Recruiting City of Hope Medical Center · Monrovia, California · NCT07266363

• NRM-823 for advanced or metastatic refractory solid tumors

  This trial tests whether NRM-823 is safe and can help people with advanced or metastatic head and neck, esophageal, gastric, or related cancers.

  Recruiting at 18 sites Phase 1 Normunity AccelCo, Inc. · Denver, Colorado and 17 other locations · NCT07182149

• ALX2004 for advanced or metastatic EGFR-expressing solid tumors

  This trial will test ALX2004, an antibody-drug conjugate that targets EGFR, in people with advanced or metastatic non-small cell lung, head and neck, esophageal, or colorectal cancer to see if it is safe and shows tumor activity.

  Recruiting at 11 sites Phase 1 ALX Oncology Inc. · La Jolla, California and 11 other locations · NCT07085091

• Neoadjuvant immunochemotherapy and chemoradiotherapy before surgery for advanced esophageal squamous cell carcinoma

  This study tests whether giving the immune drug tislelizumab with chemotherapy before and then combining chemoradiotherapy, followed by surgery, helps people with locally advanced esophageal squamous cell carcinoma.

  Recruiting Phase 2 National Taiwan University Hospital · Taipei · NCT06764355

• Using trilaciclib to prevent bone marrow suppression in esophageal cancer treatment

  This study is testing if giving trilaciclib before chemotherapy can help prevent bone marrow problems in people with esophageal cancer.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06698692

• AK112 combined with chemotherapy for advanced esophageal cancer

  This study is testing if a new drug called AK112, when combined with chemotherapy, can help people with advanced esophageal cancer who haven't had treatment before.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06489197

• First-in-human use of JAB-8263 in adults with advanced solid and blood cancers

  This trial will try JAB-8263, a BET inhibitor pill, in adults with advanced solid tumors or blood cancers that have progressed after standard treatments.

  Recruiting Phase 1/2 Jacobio Pharmaceuticals Co., Ltd. · Tianjin, Tianjin Municipality · NCT04686682

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A new test for early detection of esophageal cancer using a swallowable capsule.

  This study is working on a simple and affordable test that uses a swallowable sponge to check for early signs of esophageal cancer, making it easier for people in the U.S. and Uganda to get diagnosed and treated sooner.

  NIH research Capsulomics, LLC · Baltimore, UNITED STATES · NIH-10921933

Related topics

Quick answers

How many ESCC clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in China (6 trials), United States (3 trials), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →