Condition

CLL/SLL clinical trials and research

• 8Clinical trials
• 21Countries

Newest CLL/SLL clinical trials

All recruiting trials (8)

• Epcoritamab given after 2nd-generation BTK inhibitors for CLL/SLL

  This trial will try giving subcutaneous epcoritamab for up to 12 cycles to adults with CLL/SLL who have been on a second‑generation BTK inhibitor for at least 12 months to see if it can deepen responses to a complete remission with undetectable MRD so therapy can be stopped.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT07108998

• LP-168 plus obinutuzumab for previously treated and BTK T474I‑mutated CLL/SLL

  This trial tests whether adding LP-168 to obinutuzumab helps people with previously treated CLL/SLL, including those with the BTK T474I gatekeeper mutation, achieve deeper remissions.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06978088

• Combining Lisaftoclax and Acalabrutinib for Newly Diagnosed CLL/SLL

  This study is testing if a new combination of two drugs, Lisaftoclax and Acalabrutinib, can work better than standard treatment for people who have just been diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma.

  Recruiting at 4 sites Phase 3 Ascentage Pharma Group Inc. · Bengbu, Anhui and 9 other locations · NCT06319456

• Investigating a new treatment for patients with CLL/SLL

  This study is testing if a new treatment combining lisaftoclax with BTK inhibitors can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma who have already been treated with BTK inhibitors.

  Recruiting at 120 sites Phase 3 Ascentage Pharma Group Inc. · Tuscon, Arizona and 134 other locations · NCT06104566

• Combining venetoclax with epcoritamab for treating relapsed or refractory CLL or SLL

  This study is testing a new combination of two treatments, venetoclax and epcoritamab, to see if they can help people with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) feel better.

  Recruiting at 25 sites Phase 1/2 Stichting Hemato-Oncologie voor Volwassenen Nederland · Melbourne and 28 other locations · NCT05791409

• Oral treatment with LP-168 for patients with certain blood cancers

  This study is testing an oral treatment called LP-168 to see if it can help adults with certain types of blood cancers that have come back or didn't respond to other treatments.

  Recruiting at 4 sites Phase 1 Newave Pharmaceutical Inc · Durham, North Carolina and 3 other locations · NCT04775745

• Retreatment with venetoclax and acalabrutinib for relapsed CLL

  This study is testing if a new combination of venetoclax and acalabrutinib can help people with relapsed chronic lymphocytic leukemia (CLL) achieve better treatment results after their previous therapy.

  Recruiting at 18 sites Phase 2 Stichting Hemato-Oncologie voor Volwassenen Nederland · Brussels and 17 other locations · NCT04523428

• Testing APG-2575 for treating chronic lymphocytic leukemia and small lymphocytic leukemia

  This study is testing a new drug called APG-2575 to see if it can safely help people with chronic lymphocytic leukemia or small lymphocytic leukemia, both on its own and when combined with other treatments.

  Recruiting at 9 sites Phase 1 Ascentage Pharma Group Inc. · Duarte, California and 8 other locations · NCT04215809

Related topics

Quick answers

How many CLL/SLL clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (5 trials), Australia (3 trials), Belgium (3 trials), Denmark (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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