Condition

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma clinical trials and research

• 11Clinical trials
• 2Countries

Newest Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma clinical trials

All recruiting trials (11)

• Pirtobrutinib for Elderly CLL: See if this BTK inhibitor helps older adults

  This study tests whether pirtobrutinib can help people aged 75 and older with chronic lymphocytic leukemia that hasn’t been treated yet.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07685717

• Tafasitamab plus Acalabrutinib and Venetoclax for newly treated CLL/SLL

  This phase II study tests a combination of tafasitamab, acalabrutinib, and venetoclax in adults who are newly diagnosed with chronic lymphocytic leukemia or small lymphocytic lymphoma to see if it is safe and effective.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT07582159

• DZD8586 plus venetoclax for CLL/SLL

  This will try DZD8586 together with venetoclax in adults with newly diagnosed or treatment‑naïve CLL/SLL who need therapy.

  Recruiting at 14 sites Phase 2 Dizal Pharmaceuticals · Hefei, Anhui and 14 other locations · NCT07154264

• DZD8586 compared with doctor’s choice treatments for relapsed/refractory CLL/SLL

  This trial will test whether the oral drug DZD8586 works better than commonly chosen treatments for adults with relapsed or refractory CLL/SLL.

  Recruiting at 2 sites Phase 3 Dizal Pharmaceuticals · Nanjing, Jiangsu and 1 other locations · NCT07139873

• LP-168 plus obinutuzumab for previously treated and BTK T474I‑mutated CLL/SLL

  This trial tests whether adding LP-168 to obinutuzumab helps people with previously treated CLL/SLL, including those with the BTK T474I gatekeeper mutation, achieve deeper remissions.

  Recruiting Phase 2 University of Cincinnati · Cincinnati, Ohio · NCT06978088

• Zanubrutinib plus sonrotoclax for relapsed or refractory B‑cell non‑Hodgkin lymphoma in underrepresented racial and ethnic groups

  This phase 1 trial tests whether combining zanubrutinib and sonrotoclax can help adults from underrepresented racial and ethnic groups whose B‑cell non‑Hodgkin lymphoma has returned or not responded to prior treatment.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT06859008

• Using acalabrutinib to treat chronic lymphocytic leukemia and small lymphocytic lymphoma

  This study is testing if acalabrutinib can safely treat people with chronic lymphocytic leukemia or small lymphocytic lymphoma who can't tolerate ibrutinib, while also keeping an eye on their heart health.

  Recruiting Phase 2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT06757647

• Treatment for patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma

  This study is testing a new drug called DZD8586 to see if it can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma whose cancer has come back or isn’t responding to other treatments.

  Recruiting at 16 sites Phase 2 Dizal Pharmaceuticals · Hefei, Anhui and 16 other locations · NCT06539182

• Effects of exercise on immune function in lymphoma patients

  This study tests how short-term and long-term exercise affects the immune system and overall well-being of patients with certain types of lymphoma.

  Recruiting at 2 sites Mayo Clinic · Scottsdale, Arizona and 1 other locations · NCT05876923

• Monitoring heart rhythms in patients starting BTK inhibitors

  This study is testing how well a heart monitor can detect new heart rhythm problems in patients starting treatment with BTK inhibitors.

  Recruiting Northwell Health · New Hyde Park, New York · NCT05643235

• Treatment for B-cell malignancies using BGB-16673

  This study is testing a new drug called BGB-16673 to see if it can safely help people with different types of B-cell cancers.

  Recruiting at 29 sites Phase 1/2 BeOne Medicines · Bengbu, Anhui and 28 other locations · NCT05294731

Related topics

Quick answers

How many Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (7 trials), China (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 1, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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