Understanding how some patients with chronic myeloid leukemia can remain healthy without treatment
Mechanisms of treatment-free remission in a mouse model of chronic myeloid leukemia
This study is looking into why some people with chronic myeloid leukemia can stay healthy without taking their medication, using mice to find out what helps them maintain remission, which could lead to better ways to manage the condition and lessen the need for long-term treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11078332 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that allow some patients with chronic myeloid leukemia (CML) to maintain remission without ongoing treatment. By studying a mouse model, the researchers aim to identify factors that contribute to treatment-free remission, where patients can stop taking tyrosine kinase inhibitors (TKIs) without experiencing a relapse. The study will involve analyzing the behavior of leukemic stem cells and their interactions within the body to uncover why some patients can remain healthy without medication. This could lead to new strategies for managing CML and reducing the need for long-term drug therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic myeloid leukemia who have achieved molecular remission and are considering stopping their TKI therapy.
Not a fit: Patients who are currently experiencing active CML or have not achieved remission may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that allow CML patients to maintain remission without the side effects and costs associated with long-term medication.
How similar studies have performed: While there have been studies on treatment-free remission in CML, this research aims to explore novel biological mechanisms that have not been fully understood, making it a potentially groundbreaking approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Van Etten, Richard a. — University of California-Irvine
- Study coordinator: Van Etten, Richard a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.