Westlake Aging Cohort: following 55+ to map aging and cognitive changes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort will collect demographic, lifestyle, clinical, neuroimaging, and multi-omics data from healthy individuals and patients with MCI, AD, PDD, and DLB to build a longitudinal database. The study aims to identify molecular signatures and biomarkers linked to neurodegenerative progression and to understand mechanisms behind cognitive decline. Data will come from repeated surveys, exams, imaging, and biological samples, enabling analyses of trajectories and potential risk factors. The project is centered in Hangzhou and leverages collaboration between Westlake University and local hospitals. It does not specify an intervention; the value lies in rich, multi-omics, longitudinal characterization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 55 and 90 years (inclusive) at baseline.
2. Availability of a companion capable of providing independent functional assessments and fluent in Chinese.
3. Willingness and ability to regularly complete required surveys and physical examinations as per study protocol.
4. MMSE scores were required to be 24-30 (inclusive) for healthy controls and MCI; and 20-24 (inclusive) for AD and DLB/PDD patients.
5. Healthy controls: CDR = 0, memory box = 0. MCI: CDR = 0.5, memory box ≥ 0.5. AD: CDR = 0.5 or 1. The DLB/PDD meets the core features of diagnosis.
6. Healthy controls exhibit no significant cognitive or functional decline. Patients with MCI have objective cognitive impairment not sufficient for an AD diagnosis. AD patients fulfill the NINCDS-ADRDA criteria. DLB/PDD patients meet their respective international consensus diagnostic criteria. Other neurodegenerative diseases meet the diagnostic criteria.

Exclusion Criteria:

1. Participants with major medical or neuropsychiatric conditions unrelated to the study purposes were excluded. These included, but were not limited to, psychiatric disorders, cancer, infectious diseases, structural brain abnormalities, and epilepsy.
2. Current use of psychoactive medications or any other drugs that may affect the study.
3. Participants with cardiac pacemakers, artificial heart valves, or metallic implants in the eyes, skin, or any other part of the body.
4. Participants with any other diseases that may affect the study.

Where it's running

• Hangzhou First People's Hospital
  Hangzhou, Zhejiang, China Recruiting
• Hangzhou Third People's Hospital
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Ju-Sheng Zheng, PhD — Westlake University
• Study coordinator: Ju-Sheng Zheng, PhD
• Email: zhengjusheng@westlake.edu.cn
• Phone: 86-0571-86915303

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.